000 02842nam a22004455i 4500
001 978-1-4419-7823-3
003 DE-He213
005 20140220084511.0
007 cr nn 008mamaa
008 110713s2010 xxu| s |||| 0|eng d
020 _a9781441978233
_9978-1-4419-7823-3
024 7 _a10.1007/978-1-4419-7823-3
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aGroßhans, Helge.
_eeditor.
245 1 0 _aRegulation of microRNAs
_h[electronic resource] /
_cedited by Helge Großhans.
264 1 _aNew York, NY :
_bSpringer US,
_c2010.
300 _aXVI, 160p. 35 illus., 6 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v700
505 0 _amicroRNA Biogenesis and Function -- Regulation of pri-miRNA Processing Through Smads -- Stimulation of pri-miR-18a Processing by hnRNP A1 -- KSRP Promotes the Maturation of a Group of miRNA Precuresors -- Hormonal Repression of miRNA Biosynthesis Through a Nuclear Steroid Hormone Receptor -- Autoregulatory Mechanisms Controlling the Microprocessor -- Regulation of pre-miRNA Processing -- The Effect of RNA Editing and ADARs on miRNA Biogenesis and Function -- miRNAs Need a Trim -- Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression -- Turnover of Mature miRNAs and siRNAs in Plants and Algae -- MicroRNases and the Regulated Degradation of Mature Animal miRNAs.
520 _aGiven this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.
650 0 _aMedicine.
650 0 _aHuman genetics.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aHuman Genetics.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441978226
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v700
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-7823-3
912 _aZDB-2-SBL
999 _c110754
_d110754