000 | 03075nam a22004215i 4500 | ||
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001 | 978-1-4419-7002-2 | ||
003 | DE-He213 | ||
005 | 20140220084511.0 | ||
007 | cr nn 008mamaa | ||
008 | 110111s2010 xxu| s |||| 0|eng d | ||
020 |
_a9781441970022 _9978-1-4419-7002-2 |
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024 | 7 |
_a10.1007/978-1-4419-7002-2 _2doi |
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050 | 4 | _aR-RZ | |
072 | 7 |
_aMBGR _2bicssc |
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072 | 7 |
_aMED000000 _2bisacsh |
|
082 | 0 | 4 |
_a610 _223 |
100 | 1 |
_aTavernarakis, Nektarios. _eeditor. |
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245 | 1 | 0 |
_aProtein Metabolism and Homeostasis in Aging _h[electronic resource] / _cedited by Nektarios Tavernarakis. |
264 | 1 |
_aBoston, MA : _bSpringer US, _c2010. |
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300 |
_aXXII, 248p. 34 illus., 4 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v694 |
|
505 | 0 | _aSynthesis, Modification and Turnover of Proteins during Aging -- Regulation of mRNA Translation as a Conserved Mechanism of Longevity Control -- Protein Synthesis and the Antagonistic Pleiotropy Hypothesis of Aging -- Proteasome Function Determines Cellular Homeostasis and the Rate of Aging -- Autophagy and Longevity: Lessons from C. elegans -- Autophagy and Aging: Lessons from Progeria Models -- Regulation of Protein Turnover by Longevity Pathways -- Protein Metabolism and Lifespan in Caenorhabditis elegans -- Mitochondrial Protein Quality Control Systems in Aging and Disease -- p38MAPK in the Senescence of Human and Murine Fibroblasts -- Protein Homeostasis in Models of Aging and Age-Related Conformational Disease -- Roles for SUMO Modification during Senescence -- Post-Translational Modification of Cellular Proteins by Ubiquitin and Ubiquitin-Like Molecules: Role in Cellular Senescence and Aging -- Sensory Influence on Homeostasis and Lifespan: Molecules and Circuits -- Regulation of Muscle Atrophy in Aging and Disease -- Confronting Cellular Heterogeneity in Studies of Protein Metabolism and Homeostasis in Aging Research. | |
520 | _aThe focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post‑translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well‑characterized factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data. | ||
650 | 0 | _aMedicine. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aBiomedicine general. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9781441970015 |
830 | 0 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v694 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4419-7002-2 |
912 | _aZDB-2-SBL | ||
999 |
_c110713 _d110713 |