000 03075nam a22004215i 4500
001 978-1-4419-7002-2
003 DE-He213
005 20140220084511.0
007 cr nn 008mamaa
008 110111s2010 xxu| s |||| 0|eng d
020 _a9781441970022
_9978-1-4419-7002-2
024 7 _a10.1007/978-1-4419-7002-2
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aTavernarakis, Nektarios.
_eeditor.
245 1 0 _aProtein Metabolism and Homeostasis in Aging
_h[electronic resource] /
_cedited by Nektarios Tavernarakis.
264 1 _aBoston, MA :
_bSpringer US,
_c2010.
300 _aXXII, 248p. 34 illus., 4 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v694
505 0 _aSynthesis, Modification and Turnover of Proteins during Aging -- Regulation of mRNA Translation as a Conserved Mechanism of Longevity Control -- Protein Synthesis and the Antagonistic Pleiotropy Hypothesis of Aging -- Proteasome Function Determines Cellular Homeostasis and the Rate of Aging -- Autophagy and Longevity: Lessons from C. elegans -- Autophagy and Aging: Lessons from Progeria Models -- Regulation of Protein Turnover by Longevity Pathways -- Protein Metabolism and Lifespan in Caenorhabditis elegans -- Mitochondrial Protein Quality Control Systems in Aging and Disease -- p38MAPK in the Senescence of Human and Murine Fibroblasts -- Protein Homeostasis in Models of Aging and Age-Related Conformational Disease -- Roles for SUMO Modification during Senescence -- Post-Translational Modification of Cellular Proteins by Ubiquitin and Ubiquitin-Like Molecules: Role in Cellular Senescence and Aging -- Sensory Influence on Homeostasis and Lifespan: Molecules and Circuits -- Regulation of Muscle Atrophy in Aging and Disease -- Confronting Cellular Heterogeneity in Studies of Protein Metabolism and Homeostasis in Aging Research.
520 _aThe focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post‑translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well‑characterized factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data.
650 0 _aMedicine.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441970015
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v694
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-7002-2
912 _aZDB-2-SBL
999 _c110713
_d110713