| 000 | 02588nam a22004215i 4500 | ||
|---|---|---|---|
| 001 | 978-1-4419-6199-0 | ||
| 003 | DE-He213 | ||
| 005 | 20140220084509.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 120403s2010 xxu| s |||| 0|eng d | ||
| 020 |
_a9781441961990 _9978-1-4419-6199-0 |
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| 024 | 7 |
_a10.1007/978-1-4419-6199-0 _2doi |
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| 050 | 4 | _aR-RZ | |
| 072 | 7 |
_aMBGR _2bicssc |
|
| 072 | 7 |
_aMED000000 _2bisacsh |
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| 082 | 0 | 4 |
_a610 _223 |
| 100 | 1 |
_aPoon, Randy Y. C. _eeditor. |
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| 245 | 1 | 0 |
_aPolyploidization and Cancer _h[electronic resource] / _cedited by Randy Y. C. Poon. |
| 264 | 1 |
_aNew York, NY : _bSpringer New York, _c2010. |
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| 300 |
_aXVI, 148p. 36 illus., 1 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
||
| 490 | 1 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v676 |
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| 505 | 0 | _aPolyploidy, Aneuploidy and the Evolution of Cancer -- Molecular Mechanisms and Function of the Spindle Checkpoint, a Guardian of the Chromosome Stability -- Understanding Cytokinesis Failure -- DNA Damage and Polyploidization -- Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization -- Centrosomes, Polyploidy and Cancer -- Polyploidy: Mechanisms and Cancer Promotion in Hematopoietic and Other Cells -- Polyploidization of liver cells -- Analysis of Cellular DNA Content by Flow and Laser Scanning Cytometry. | |
| 520 | _aLimiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aBiomedicine general. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9781441961983 |
| 830 | 0 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v676 |
|
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4419-6199-0 |
| 912 | _aZDB-2-SBL | ||
| 999 |
_c110591 _d110591 |
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