000			04345nam a22004335i 4500
001			978-1-4419-5819-8
003			DE-He213
005			20140220084508.0
007			cr nn 008mamaa
008			101231s2010 xxu| s |||| 0|eng d
020			_a9781441958198 _9978-1-4419-5819-8
024	7		_a10.1007/978-1-4419-5819-8 _2doi
050		4	_aRC321-580
072		7	_aPSAN _2bicssc
072		7	_aMED057000 _2bisacsh
082	0	4	_a612.8 _223
100	1		_aJandial, Rahul. _eeditor.
245	1	0	_aFrontiers in Brain Repair _h[electronic resource] / _cedited by Rahul Jandial.
264		1	_aNew York, NY : _bSpringer New York, _c2010.
300			_aXVIII, 130p. 42 illus. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v671
505	0		_aIn Vivo Imaging of Cellular Transplants -- Culture and Manipulation of Neural Stem Cells -- Animal Models of Neurological Disease -- Stem Cell Transplantation Methods -- Stem Cell Origin of Brain Tumors -- The Tumor Microenvironment -- Exploitation of Genetically Modified Neural Stem Cells for Neurological Disease -- Biological Horizons for Targeting Brain Malignancy -- Stem Cells in the Treatment of Stroke -- Gene- and Cell-Based Approaches for Neurodegenerative Disease.
520			_aIn the rapidly-evolving landscape of neurosciences, it is no easy task to select a limited array of topics to present in a text such as this. The current volume takes as its purpose to provide a representative survey of the current science of brain repair for those seeking to establish a foundation in the field or to replenish a prior knowledge base that may have lapsed in its currency. It also hopes to offer insights into what remains elusive to our collective investigations, defining the “frontiers” of brain repair for those that are currently immersed in the exciting intersection of biological advances and neuroscientific discoveries. In Chapter 1 the fundamentals of imaging transplanted cells is discussed with emphasis on animal models as well as the horizon for clinical trials. Then, detailed methods on the culture of neural stem cells is reviewed as a foundation for approaching therapeutic goals. Chapter 3 presents the broad scope of animal models that serve as the foundation for developmental and pre-clinical investigation, with mention of recent genetically engineered mouse models that represent the best models for studying disease development and treatment. Chapter 4 provides background on the delivery techniques to animals and patients that are available, providing vital information on the subtleties of technique necessary for optimal cellular grafting. Chapters 5 and 6 discuss new and evolving information on the origins of brain tumors and the indelible role of stromal and microenvironmental influences on oncogenesis and tumor progression. Subsequently, the utility of neural stem cells as cellular vehicles to deliver chemotherapeutics to broad neuropathology is reviewed. In Chapter 8 the scope of treating brain tumors is expanded beyond stem cells, to present the best biological interventions to improve upon current treatment options for brain malignancy. The last two chapters present a comprehensive review on stem cell and gene therapy options for treating cerebrovascular and neurovascular pathology. In amassing this collection, my intention has been to provide the reader with a broad introduction into molecular imaging, stem cell biology, cell therapy, animal models, central nervous system malignancies, stroke, and neurodegeneration. My hope is that Frontiers of Brain Repair will be the intellectual soil from which a deeply rooted and well-nourished vintage of neuroscience will arise.
650		0	_aMedicine.
650		0	_aNeurosciences.
650	1	4	_aBiomedicine.
650	2	4	_aNeurosciences.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441958181
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v671
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4419-5819-8
912			_aZDB-2-SBL
999			_c110534 _d110534