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001 978-1-4419-0996-1
003 DE-He213
005 20140220084504.0
007 cr nn 008mamaa
008 100715s2010 xxu| s |||| 0|eng d
020 _a9781441909961
_9978-1-4419-0996-1
024 7 _a10.1007/978-1-4419-0996-1
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
100 1 _aCutsuridis, Vassilis.
_eeditor.
245 1 0 _aHippocampal Microcircuits
_h[electronic resource] :
_bA Computational Modeler’s Resource Book /
_cedited by Vassilis Cutsuridis, Bruce Graham, Stuart Cobb, Imre Vida.
264 1 _aNew York, NY :
_bSpringer New York,
_c2010.
300 _aApprox. 450 p. 109 illus., 44 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringer Series in Computational Neuroscience ;
_v5
505 0 _aExperimental Background -- Connectivity of the Hippocampus -- Morphology of Hippocampal Neurons -- Physiological Properties of Hippocampal Neurons -- Glutamatergic Neurotransmission in the Hippocampus -- Fast and Slow GABAergic Transmission in Hippocampal Circuits -- Synaptic Plasticity at Hippocampal Synapses -- Neuromodulation of Hippocampal Cells and Circuits -- Neuronal Activity Patterns During Hippocampal Network Oscillations In Vitro -- Neuronal Activity Patterns in Anaesthetized Animals -- Spatial and Behavioral Correlates of Hippocampal Neuronal Activity: A Primer for Computational Analysis -- Computational Analysis -- The Making of a Detailed CA1 Pyramidal Neuron Model -- CA3 Cells: Detailed and Simplified Pyramidal Cell Models -- Entorhinal Cortex Cells -- Single Neuron Models: Interneurons -- Gamma and Theta Rhythms in Biophysical Models of Hippocampal Circuits -- Associative Memory Models of Hippocampal Areas CA1 and CA3 -- Microcircuit Model of the Dentate Gyrus in Epilepsy -- Multi-level Models -- Biophysics-Based Models of LTP/LTD -- A Phenomenological Calcium-Based Model of STDP -- Computer Simulation Environments.
520 _aThe hippocampus plays an indispensible role in the formation of new memories in the mammalian brain. It is the focus of intense research and our understanding of its physiology, anatomy, and molecular structure has rapidly expanded in recent years. Yet, still much needs to be done to decipher how hippocampal microcircuits are built and function. Here, we present an overview of our current knowledge and a snapshot of ongoing research into these microcircuits. Rich in detail, Hippocampal Microcircuits: A Computational Modeler’s Resource Book provides focused and easily accessible reviews on various aspects of the theme. It is an unparalleled resource of information, including both data and techniques that will be an invaluable companion to all those wishing to develop computational models of hippocampal neurons and neuronal networks. The book is divided into two main parts. In the first part, leading experimental neuroscientists discuss data on the electrophysiological, neuroanatomical, and molecular characteristics of hippocampal circuits. The various types of excitatory and inhibitory neurons are reviewed along with their connectivity and synaptic properties. Single cell and ensemble activity patterns are presented from in vitro models, as well as anesthetized and freely moving animals. In the second part, computational neuroscientists describe models of hippocampal microcircuits at various levels of complexity, from single neurons to large-scale networks. Additionally, a chapter is devoted to simulation environments currently used by computational neuroscientists in developing their models. In addition to providing concise reviews and a wealth of data, the chapters also identify central questions and unexplored areas that will define future research in computational neuroscience. About the Editors: Dr. Vassilis Cutsuridis is a Research Fellow in the Department of Computing Science and Mathematics at the University of Stirling, Scotland, UK. Dr. Bruce P. Graham is a Reader in Computing Science in the Department of Computing Science and Mathematics at the University of Stirling. Dr. Stuart Cobb and Dr. Imre Vida are Senior Lecturers in the Neuroscience and Molecular Pharmacology Department at the University of Glasgow, Scotland, UK.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 0 _aBiology
_xData processing.
650 0 _aNeurobiology.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
650 2 4 _aNeurobiology.
650 2 4 _aComputer Appl. in Life Sciences.
700 1 _aGraham, Bruce.
_eeditor.
700 1 _aCobb, Stuart.
_eeditor.
700 1 _aVida, Imre.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441909954
830 0 _aSpringer Series in Computational Neuroscience ;
_v5
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-0996-1
912 _aZDB-2-SBL
999 _c110292
_d110292