000			03070nam a22004815i 4500
001			978-1-4419-0814-8
003			DE-He213
005			20140220084503.0
007			cr nn 008mamaa
008			100301s2010 xxu| s |||| 0|eng d
020			_a9781441908148 _9978-1-4419-0814-8
024	7		_a10.1007/978-1-4419-0814-8 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aZent, Roy. _eeditor.
245	1	0	_aCell-Extracellular Matrix Interactions in Cancer _h[electronic resource] / _cedited by Roy Zent, Ambra Pozzi.
250			_a1.
264		1	_aNew York, NY : _bSpringer New York, _c2010.
300			_aXII, 314p. 22 illus., 11 illus. in color. With 1 4-page color insert. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aThe Extracellular Matrix: An Overview -- Integrin Structure and Function -- Cancer in Context: Importance of the Tumor Microenvironment -- Basement Membrane Collagens and Cancer -- Laminins and Cancer Progression -- Fibronectins and Their Receptors in Cancer -- Vitronectin-Binding Integrins in Cancer -- The Function of SPARC in Tumor Cell Biology: SPARC as a Modulator of Cell–Extracellular Matrix Interaction -- Proteoglycans and Cancer -- Tetraspanins in Cancer -- The Role of Integrin-Linked Kinase in Cancer Development and Progression -- Focal Adhesion Kinase with the Interacting Proteins and Signaling in Cancer.
520			_aCells require interactions with extracellular matrix (ECM) components in order to undergo normal morphogenesis with respect to organogenesis. ECM plays a significant role in regulating numerous cellular functions, like cell shape, adhesion, migration, proliferation, polarity, differentiation and apoptosis. In pathological conditions such as cancer, increased synthesis of certain ECM components and/or increased breakdown with consequent generation of ECM cleavage products can contribute to cancer growth and progression. That many growth factors (i.e. FGF, VEGF) are stored in the ECM milieu and are released upon protease-dependent cleavage further confirms the importance of ECM in regulating cell functions. Cell-Extracellular Matrix Interactions in Cancer describes how ECM creates a niche for tumor formation and the contribution of ECM components and their respective receptors in the development and spread of cancer.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aToxicology.
650		0	_aCytology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aCell Biology.
650	2	4	_aPharmacology/Toxicology.
700	1		_aPozzi, Ambra. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441908131
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4419-0814-8
912			_aZDB-2-SBL
999			_c110258 _d110258