000			03245nam a22004455i 4500
001			978-0-387-93846-2
003			DE-He213
005			20140220084457.0
007			cr nn 008mamaa
008			100721s2010 xxu| s |||| 0|eng d
020			_a9780387938462 _9978-0-387-93846-2
024	7		_a10.1007/978-0-387-93846-2 _2doi
050		4	_aRC254-282
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a616.994 _223
100	1		_aChung, Daniel C. _eeditor.
245	1	0	_aPrinciples of Clinical Cancer Genetics _h[electronic resource] : _bA Handbook from the Massachusetts General Hospital / _cedited by Daniel C. Chung, Daniel A. Haber.
264		1	_aBoston, MA : _bSpringer US : _bImprint: Springer, _c2010.
300			_aX, 227p. 48 illus., 46 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aBasic Principles of Cancer Genetics -- Principles of Cancer Genetic Counseling and Genetic Testing -- Genetics of Hereditary Breast Cancer -- Surgical Management of Hereditary Breast and Ovarian Cancer -- Hereditary Colon Cancer: Colonic Polyposis Syndromes -- Hereditary Colon Cancer: Lynch Syndrome -- Hereditary Pancreatic Cancer -- Hereditary Diffuse Gastric Cancer -- Familial Renal Cell Cancers and Pheochromocytomas -- Familial Atypical Mole Melanoma (FAMM) Syndrome -- Multiple Endocrine Neoplasia -- Pediatric Malignancies: Retinoblastoma and Wilms’ Tumor -- Neurofibromatosis and Schwannomatosis -- The HapMap Project and Low-Penetrance Cancer Susceptibility Alleles -- Somatic Genetic Alterations and Implications for Targeted Therapies in Cancer (GIST, CML, Lung Cancer).
520			_aAdvances in genetics are transforming estimates of an individual’s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed. In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aOncology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aOncology.
650	2	4	_aHuman Genetics.
700	1		_aHaber, Daniel A. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387938448
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-93846-2
912			_aZDB-2-SME
999			_c109876 _d109876