000 03623nam a22005055i 4500
001 978-94-007-0495-4
003 DE-He213
005 20140220083830.0
007 cr nn 008mamaa
008 110401s2011 ne | s |||| 0|eng d
020 _a9789400704954
_9978-94-007-0495-4
024 7 _a10.1007/978-94-007-0495-4
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aDas, Undurti N.
_eauthor.
245 1 0 _aMolecular Basis of Health and Disease
_h[electronic resource] /
_cby Undurti N. Das.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2011.
300 _aXX, 583p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aAbout the Author -- Preface -- Dedication -- Chapter 1: Introduction -- Chapter 2: Health and Disease as two sides of the same coin -- Chapter 3: Inflammation -- Chapter 4: Essential fatty acids-Biochemistry, Physiology and Clinical Significance -- Chapter 5: Cell membrane organization -- Chapter 6: Low-grade systemic inflammation is common in iseases/disorders -- Chapter 7: Obesity -- Chapter 8: Hypertension -- Chapter 9: Insulin resistance, dyslipidemia, type 2 diabetes Mellitus and metabolic syndrome -- Chapter 10: Atherosclerosis -- Chapter 11: Osteoporosis -- Chapter 12: Alzheimer’s disease, schizophrenia and depression -- Chapter 13: Rheumatological conditions -- Chapter 14: Cancer -- Chapter 15: Aging -- Chapter 16: Adult diseases and low-grade systemic inflammation  have their origins in the perinatal period -- Chapter 17: Clinical implications.
520 _aThe book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aInternal medicine.
650 0 _aDiabetes.
650 0 _aEndocrinology.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aHuman Physiology.
650 2 4 _aMolecular Medicine.
650 2 4 _aInternal Medicine.
650 2 4 _aDiabetes.
650 2 4 _aEndocrinology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400704947
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-0495-4
912 _aZDB-2-SBL
999 _c109303
_d109303