000 04452nam a22005415i 4500
001 978-3-642-21625-1
003 DE-He213
005 20140220083805.0
007 cr nn 008mamaa
008 110830s2011 gw | s |||| 0|eng d
020 _a9783642216251
_9978-3-642-21625-1
024 7 _a10.1007/978-3-642-21625-1
_2doi
050 4 _aQH359-425
072 7 _aPSAJ
_2bicssc
072 7 _aSCI027000
_2bisacsh
082 0 4 _a576.8
_223
100 1 _aEgel, Richard.
_eeditor.
245 1 0 _aOrigins of Life: The Primal Self-Organization
_h[electronic resource] /
_cedited by Richard Egel, Dirk-Henner Lankenau, Armen Y. Mulkidjanian.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2011.
300 _aVIII, 300p. 65 illus., 24 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aEnergy as the Common Denominator: Energetics of the First Life -- A Hypothesis for a Unified Mechanism of Formation and Enantioenrichment of Polyols and Aldaric, Aldonic, Amino, Hydroxy and Sugar Acids in Carbonaceous Chondrites -- On the Origin of Phosphorylated Biomolecules -- Abiotic Photosynthesis: From Prebiotic Chemistry to Metabolism -- Salt-Induced Peptide Formation in Chemical Evolution: Building Blocks before RNA - Potential of Peptide Splicing Reactions -- Scenario of the Primary Pump: Emergence and Operation of an Automatic Engine to Generate Primordial Peptides and Beyond Nucleic Acids -- The Relevance of Peptides that Bind FeS Clusters, Phosphate Groups, Cations or Anions for Prebiotic Evolution -- Peptide-Dominated Vesicles: Bacterial Internal Membrane Compartments as Model Systems for Prebiotic Evolution -- Nicotinamide Coenzyme Synthesis: a Case of Ribonucleotide Emergence or a Byproduct of the RNA World?- On Alternative Biological Scenarios for the Evolutionary Transitions to DNA and Biological Protein Synthesis -- Two RNA Worlds: Toward the Origin of Replication, Genes, Recombination and Repair -- Integrative Perspectives: In Quest of a Coherent Framework for Origins of Life on Earth.
520 _aIf theoretical physicists can seriously entertain canonical “standard models” even for the big-bang generation of the entire universe, why cannot life scientists reach a consensus on how life has emerged and settled on this planet?  Scientists are hindered by conceptual gaps between bottom-up inferences (from early Earth geological conditions) and top-down extrapolations (from modern life forms to common ancestral states). This book challenges several widely held assumptions and argues for alternative approaches instead. Primal syntheses (literally or figuratively speaking) are called for in at least five major areas. (1) The first RNA-like molecules may have been selected by solar light as being exceptionally photostable. (2) Photosynthetically active minerals and reduced phosphorus compounds could have efficiently coupled the persistent natural energy flows to the primordial metabolism. (3) Stochastic, uncoded peptides may have kick-started an ever-tightening co-evolution of proteins and nucleic acids.  (4) The living fossils from the primeval RNA World thrive within modern cells.  (5) From the inherently complex protocellular associations preceding the consolidation of integral genomes, eukaryotic cell organization may have evolved more naturally than simple prokaryote-like life forms. – If this book can motivate dedicated researchers to further explore the alternative mechanisms presented, it will have served its purpose well.
650 0 _aLife sciences.
650 0 _aPaleontology.
650 0 _aBiochemistry.
650 0 _aNucleic acids.
650 0 _aCytology.
650 0 _aEvolution (Biology).
650 1 4 _aLife Sciences.
650 2 4 _aEvolutionary Biology.
650 2 4 _aBiochemistry, general.
650 2 4 _aPaleontology.
650 2 4 _aNucleic Acid Chemistry.
650 2 4 _aProtein Science.
650 2 4 _aCell Biology.
700 1 _aLankenau, Dirk-Henner.
_eeditor.
700 1 _aMulkidjanian, Armen Y.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642216244
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-21625-1
912 _aZDB-2-SBL
999 _c108029
_d108029