000			03714nam a22005055i 4500
001			978-3-642-21078-5
003			DE-He213
005			20140220083803.0
007			cr nn 008mamaa
008			110728s2011 gw | s |||| 0|eng d
020			_a9783642210785 _9978-3-642-21078-5
024	7		_a10.1007/978-3-642-21078-5 _2doi
050		4	_aQD431-431.7
072		7	_aPSBZ _2bicssc
072		7	_aSCI007000 _2bisacsh
082	0	4	_a572.6 _223
100	1		_aNicholson, Allen W. _eeditor.
245	1	0	_aRibonucleases _h[electronic resource] / _cedited by Allen W. Nicholson.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2011.
300			_aXIV, 406 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aNucleic Acids and Molecular Biology, _x0933-1891
505	0		_aThe Superfamily of Vertebrate Secreted Ribonucleases -- Vertebrate Secretory (RNase A) Ribonucleases and Host Defense -- Antitumor Ribonucleases -- RNase T2 family: enzymatic properties, functional diversity, and evolution of ancient ribonucleases -- Stress-induced Ribonucleases -- Viral RNase Involvement in Strategies of Infection -- 5’-3’ exoribonucleases -- Structure and degradation mechanisms of 3’ to 5’ exoribonucleases -- The RNA exosomes -- The Metallo--Lactamase Family of Ribonucleases -- Ribonuclease III and the Role of Double-Stranded RNA Processing in Bacterial Systems -- Structure and function of RNase H enzymes -- Ribonucleoprotein Ribonucleases P and MRP -- Nonenzymatic and Metal-ion-dependent RNA Cleavage, and RNase Models -- Ribonucleases as Models for Understanding Protein Folding.
520			_aRibonucleases are a ubiquitous and functionally diverse group of enzymes that have a common ability to cleave RNA. Either through scission of internal phosphodiesters, or removal of nucleotides from RNA 5’ or 3’ ends, ribonucleases perform essential roles in gene expression and regulation, genome replication and maintenance, host defense, stress response, and viral strategies of infection. Ribonucleases have also served as highly informative models to understand virtually every aspect of biomolecular structure and function. The fifteen chapters in this volume are written by recognized researchers in the field, and provide in-depth analyses of the major ribonuclease families. Particular focus is given to the relation of ribonuclease structure and mechanism to biological function, as well as ribonuclease dysfunction in certain disease states. Other topics include the evolutionary genetics and functional diversification of ribonucleases, engineered ribonucleases as anti-cancer agents, the mechanisms of action of artificial ribonucleases, and ribonucleases as models to understand protein folding and stability. This volume should serve as an essential reference for a broad range of researchers and educators with interests in RNA metabolism, enzymology, and gene regulation.
650		0	_aLife sciences.
650		0	_aMedicine.
650		0	_aNucleic acids.
650		0	_aEnzymes.
650		0	_aCytology.
650	1	4	_aLife Sciences.
650	2	4	_aEnzymology.
650	2	4	_aNucleic Acid Chemistry.
650	2	4	_aCell Biology.
650	2	4	_aMolecular Medicine.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642210778
830		0	_aNucleic Acids and Molecular Biology, _x0933-1891
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-21078-5
912			_aZDB-2-SBL
999			_c107900 _d107900