000 03168nam a22004695i 4500
001 978-3-642-19922-6
003 DE-He213
005 20140220083758.0
007 cr nn 008mamaa
008 110621s2011 gw | s |||| 0|eng d
020 _a9783642199226
_9978-3-642-19922-6
024 7 _a10.1007/978-3-642-19922-6
_2doi
050 4 _aRS400-431
072 7 _aPSB
_2bicssc
072 7 _aSCI013020
_2bisacsh
082 0 4 _a615.19
_223
100 1 _aGupta, Satya Prakash.
_eeditor.
245 1 0 _aIon Channels and Their Inhibitors
_h[electronic resource] /
_cedited by Satya Prakash Gupta.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2011.
300 _aXIII, 300p. 55 illus., 12 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aStructural and Functional Discrimination of Membrane -- Proteins -- Pharmacology of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels -- Advanced Molecular Modeling Techniques Applied to Ion Channels Blockers -- Advances in Design and Development of Sodium Channel Blockers -- Potassium Channel Blockers as Anti-arrhythmic Agents.-  hERG Potassium Channels in Drug Discovery and Development -- Prediction of hERG Channel Inhibition Using in silico Techniques -- Advances in Structure-Activity Relationship Studies on Potassium Channel Modulators -- Calcium Ion Channels and Their Blockers -- Therapeutic Potential of N-type Voltage Gated Ca2+ Channel -- Chloride Ion Channels: Structure, Functions, and Blockers.
520 _aBeing the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, neurobiology, and medicinal chemistry.
650 0 _aChemistry.
650 0 _aMedicine.
650 0 _aBiochemistry.
650 0 _aPharmacy.
650 1 4 _aChemistry.
650 2 4 _aMedicinal Chemistry.
650 2 4 _aMolecular Medicine.
650 2 4 _aProtein Science.
650 2 4 _aPharmacy.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642199219
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-19922-6
912 _aZDB-2-CMS
999 _c107675
_d107675