| 000 | 02471nam a22005535i 4500 | ||
|---|---|---|---|
| 001 | 978-3-642-17969-3 | ||
| 003 | DE-He213 | ||
| 005 | 20140220083752.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 110621s2011 gw | s |||| 0|eng d | ||
| 020 |
_a9783642179693 _9978-3-642-17969-3 |
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| 024 | 7 |
_a10.1007/978-3-642-17969-3 _2doi |
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| 050 | 4 | _aRM1-950 | |
| 072 | 7 |
_aMMG _2bicssc |
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| 072 | 7 |
_aMED071000 _2bisacsh |
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| 082 | 0 | 4 |
_a615 _223 |
| 100 | 1 |
_aFrancis, Sharron H. _eeditor. |
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| 245 | 1 | 0 |
_aPhosphodiesterases as Drug Targets _h[electronic resource] / _cedited by Sharron H. Francis, Marco Conti, Miles D. Houslay. |
| 264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2011. |
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| 300 |
_aXVIII, 522 p. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 |
_aHandbook of Experimental Pharmacology, _x0171-2004 ; _v204 |
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| 520 | _aCyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aToxicology. | |
| 650 | 0 | _aBiochemistry. | |
| 650 | 0 | _aEnzymes. | |
| 650 | 0 | _aPost-translational modification of proteins. | |
| 650 | 0 | _aCytology. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aPharmacology/Toxicology. |
| 650 | 2 | 4 | _aMedicinal Chemistry. |
| 650 | 2 | 4 | _aProtein Structure. |
| 650 | 2 | 4 | _aEnzymology. |
| 650 | 2 | 4 | _aPosttranslational Modification. |
| 650 | 2 | 4 | _aCell Physiology. |
| 700 | 1 |
_aConti, Marco. _eeditor. |
|
| 700 | 1 |
_aHouslay, Miles D. _eeditor. |
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| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9783642179686 |
| 830 | 0 |
_aHandbook of Experimental Pharmacology, _x0171-2004 ; _v204 |
|
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-642-17969-3 |
| 912 | _aZDB-2-SBL | ||
| 999 |
_c107339 _d107339 |
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