000 02908nam a22004335i 4500
001 978-3-642-17083-6
003 DE-He213
005 20140220083750.0
007 cr nn 008mamaa
008 110117s2011 gw | s |||| 0|eng d
020 _a9783642170836
_9978-3-642-17083-6
024 7 _a10.1007/978-3-642-17083-6
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aVassilev, Lyubomir.
_eeditor.
245 1 0 _aSmall-Molecule Inhibitors of Protein-Protein Interactions
_h[electronic resource] /
_cedited by Lyubomir Vassilev, David Fry.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2011.
300 _aX, 174 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v348
505 0 _aPreface -- Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions -- Small-molecule inhibitors of IL-2/IL-2R: lessons learned and applied -- Small Molecule Inhibitors of the Human Papillomavirus E1-E2 Interaction -- Design of small-molecule Smac mimetics as IAP antagonists -- Small-molecule inhibitors reveal a new function for Bcl-2 as a pro-angiogenic signaling molecule -- Small-molecule modulators of c-Myc/Max and Max/Max interactions.-  Small-molecule inhibitors of the p53-MDM2 interaction -- Subject index.
520 _abody> In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions. The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. There are various focal points, including methodologies and the molecules themselves. Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field.
650 0 _aMedicine.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
700 1 _aFry, David.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642170829
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v348
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-17083-6
912 _aZDB-2-SBL
999 _c107219
_d107219