000			03333nam a22005055i 4500
001			978-3-642-16861-1
003			DE-He213
005			20140220083750.0
007			cr nn 008mamaa
008			110407s2011 gw | s |||| 0|eng d
020			_a9783642168611 _9978-3-642-16861-1
024	7		_a10.1007/978-3-642-16861-1 _2doi
050		4	_aQH573-671
072		7	_aPSF _2bicssc
072		7	_aSCI049000 _2bisacsh
082	0	4	_a571.6 _223
100	1		_aParks, William C. _eeditor.
245	1	0	_aExtracellular Matrix Degradation _h[electronic resource] / _cedited by William C. Parks, Robert P. Mecham.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2011.
300			_aX, 255 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aBiology of Extracellular Matrix ; _v2
505	0		_aMatrix Metalloproteinases and Their Inhibitors in Turnover and Degradation of Extracellular Matrix -- Role of Cysteine Cathepsins in Extracellular Proteolysis -- Cooperation between proteolysis and endocytosis in collagen turnover -- Pericellular Proteolysis -- Triple Helicase Activity and the Structural Basis of Collagenolysis -- Structural Basis of Extracellular Matrix Interactions with Matrix Metalloproteinases -- The Role of Matrix Metalloproteinases in Cellular Invasion and Metastasis -- Degradation of bone and the role of osteoclasts, bone lining cells and osteocytes -- Consequences of Elastolysis.
520			_aRegulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
650		0	_aLife sciences.
650		0	_aMedicine.
650		0	_aBiochemistry.
650		0	_aCytology.
650	1	4	_aLife Sciences.
650	2	4	_aCell Biology.
650	2	4	_aBiochemistry, general.
650	2	4	_aProtein Science.
650	2	4	_aMolecular Medicine.
700	1		_aMecham, Robert P. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642168604
830		0	_aBiology of Extracellular Matrix ; _v2
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-16861-1
912			_aZDB-2-SBL
999			_c107206 _d107206