000 03391nam a22005415i 4500
001 978-3-642-16502-3
003 DE-He213
005 20140220083749.0
007 cr nn 008mamaa
008 110201s2011 gw | s |||| 0|eng d
020 _a9783642165023
_9978-3-642-16502-3
024 7 _a10.1007/978-3-642-16502-3
_2doi
050 4 _aQH345
050 4 _aQD415-436
072 7 _aPSB
_2bicssc
072 7 _aSCI007000
_2bisacsh
082 0 4 _a572
_223
100 1 _aUgarkovic, Durdica.
_eeditor.
245 1 0 _aLong Non-Coding RNAs
_h[electronic resource] /
_cedited by Durdica Ugarkovic.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2011.
300 _aXII, 208 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aProgress in Molecular and Subcellular Biology,
_x0079-6484 ;
_v51
505 0 _aTranscriptional and post-transcriptional programming by long noncoding RNAs -- Long noncoding RNA as a regulator for transcription -- Long non-coding RNAs and X chromosome inactivation -- TERRA: long non-coding RNA at eukaryotic telomeres -- Transcription of satellite DNAs in mammals -- Multiple roles of Alu-related non-coding RNAs -- roX RNAs and genome regulation in Drosophila melanogaster -- Transcription of satellite DNAs in insects -- Long non-protein-coding RNAs in plants.
520 _aLong non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs. This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dosage compensation in flies and mammals is described, as well as their role in centromere and telomere biology. Long non-coding RNAs involved in environmental stress response and development are presented and their mechanisms of action discussed.
650 0 _aLife sciences.
650 0 _aMedical genetics.
650 0 _aMedicine.
650 0 _aBiochemistry.
650 0 _aNucleic acids.
650 0 _aCytology.
650 1 4 _aLife Sciences.
650 2 4 _aBiochemistry, general.
650 2 4 _aNucleic Acid Chemistry.
650 2 4 _aCell Biology.
650 2 4 _aGene Function.
650 2 4 _aMolecular Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642165016
830 0 _aProgress in Molecular and Subcellular Biology,
_x0079-6484 ;
_v51
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-16502-3
912 _aZDB-2-SBL
999 _c107160
_d107160