000 03043nam a22004575i 4500
001 978-3-642-14429-5
003 DE-He213
005 20140220083745.0
007 cr nn 008mamaa
008 101109s2011 gw | s |||| 0|eng d
020 _a9783642144295
_9978-3-642-14429-5
024 7 _a10.1007/978-3-642-14429-5
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
100 1 _aBalogh, Peter.
_eeditor.
245 1 0 _aDevelopmental Biology of Peripheral Lymphoid Organs
_h[electronic resource] /
_cedited by Peter Balogh.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2011.
300 _aX, 177p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroduction: Evolution of peripheral lymphoid organs -- Common themes in lymphoid organ development -- Development of lymph nodes in humans and rodents -- Programmed and nascent gut-associated organized lymphoid tissues -- Single complexity: the spleen -- Age-associated decline in peripheral lymphoid organ functions.
520 _aThe human immune system is a complex network of tissues and organs dispersed throughout the body. Immunology, as one of the most rapidly evolving fields in biomedical research, has to date covered the essential cellular and molecular events necessary for immune responses to occur, but has paid relatively little attention to important developmental processes underlying the formation of the tissues themselves that carry out immune responses in humans and other mammalians. In contrast to the thymus and bone marrow that generate mature leukocytes for antigen recognition and handling, these latter tissues display broad tissue distribution and possess diverse architectural characteristics. These peripheral lymphoid tissues and organs develop prior to the individual’s exposure to external antigens, and despite their similar functions, their varied appearances indicate a substantial complexity of tissue ontogeny. This volume presents a comprehensive overview of the developmental features of the major peripheral lymphoid organs, thus examining the connection between immunological functionality and structural characteristics utilizing a developmental approach, for an audience ranging from undergraduate students to senior researchers in immunology, histology and clinical medicine.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aImmunology.
650 0 _aDevelopmental biology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aDevelopmental Biology.
650 2 4 _aHuman Physiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642144288
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-14429-5
912 _aZDB-2-SBL
999 _c106953
_d106953