000 | 03410nam a22005055i 4500 | ||
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001 | 978-3-211-99079-7 | ||
003 | DE-He213 | ||
005 | 20140220083739.0 | ||
007 | cr nn 008mamaa | ||
008 | 110406s2011 au | s |||| 0|eng d | ||
020 |
_a9783211990797 _9978-3-211-99079-7 |
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024 | 7 |
_a10.1007/978-3-211-99079-7 _2doi |
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050 | 4 | _aQD146-197 | |
072 | 7 |
_aPNK _2bicssc |
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072 | 7 |
_aSCI013030 _2bisacsh |
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082 | 0 | 4 |
_a546 _223 |
100 | 1 |
_aAldrich-Wright, Janice. _eeditor. |
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245 | 1 | 0 |
_aMetallointercalators _h[electronic resource] : _bSynthesis and Techniques to Probe Their Interactions with Biomolecules / _cedited by Janice Aldrich-Wright. |
264 | 1 |
_aVienna : _bSpringer Vienna : _bImprint: Springer, _c2011. |
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300 |
_aXXVIII, 427p. 120 illus., 40 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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505 | 0 | _aIntroduction -- Synthesis:Platinum Intercalating Complexes; Binuclear Platinum Complexes;Binuclear Ruthenium and Platinum Intercalating Complexes; Sequence Selective Intercalating Complexes; Targeting and Improving Transport, Cucurbit[n]uril, Cylcodextrin and Dendrimers -- Techniques to Probe Interactions with Biomolecules:Introduction to NMR; DNA-NMR; PGSE-NMR; DNA ESI-MS; Investigating Binding Interactions using Linear Dichromism and Circular Dichromism; Flourescence Spectroscopy; Confocal Microscopy; Implementation of synchotron X-ray microscopy for investigations of the cellular uptake and cellular metabolism of metallointercalators; Biomolecular Helical Structure; Viscosity, TGA and Dialysis; Microarrays; Cytotoxicity-Cell lines; Antibacterical activity; Animal testing. | |
520 | _aA comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery. | ||
650 | 0 | _aChemistry. | |
650 | 0 | _aSpectroscopy. | |
650 | 0 | _aChemistry, inorganic. | |
650 | 0 | _aChemistry, Physical organic. | |
650 | 0 | _aPharmacy. | |
650 | 0 | _aBiochemistry. | |
650 | 1 | 4 | _aChemistry. |
650 | 2 | 4 | _aInorganic Chemistry. |
650 | 2 | 4 | _aPharmacy. |
650 | 2 | 4 | _aBiochemistry, general. |
650 | 2 | 4 | _aPhysical Chemistry. |
650 | 2 | 4 | _aSpectroscopy/Spectrometry. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783211094273 |
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-211-99079-7 |
912 | _aZDB-2-CMS | ||
999 |
_c106612 _d106612 |