000 03410nam a22005055i 4500
001 978-3-211-99079-7
003 DE-He213
005 20140220083739.0
007 cr nn 008mamaa
008 110406s2011 au | s |||| 0|eng d
020 _a9783211990797
_9978-3-211-99079-7
024 7 _a10.1007/978-3-211-99079-7
_2doi
050 4 _aQD146-197
072 7 _aPNK
_2bicssc
072 7 _aSCI013030
_2bisacsh
082 0 4 _a546
_223
100 1 _aAldrich-Wright, Janice.
_eeditor.
245 1 0 _aMetallointercalators
_h[electronic resource] :
_bSynthesis and Techniques to Probe Their Interactions with Biomolecules /
_cedited by Janice Aldrich-Wright.
264 1 _aVienna :
_bSpringer Vienna :
_bImprint: Springer,
_c2011.
300 _aXXVIII, 427p. 120 illus., 40 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroduction -- Synthesis:Platinum Intercalating Complexes; Binuclear Platinum Complexes;Binuclear Ruthenium and Platinum Intercalating Complexes; Sequence Selective Intercalating Complexes; Targeting and Improving Transport, Cucurbit[n]uril, Cylcodextrin and Dendrimers -- Techniques to Probe Interactions with Biomolecules:Introduction to NMR; DNA-NMR; PGSE-NMR; DNA ESI-MS; Investigating Binding Interactions using Linear Dichromism and Circular Dichromism; Flourescence Spectroscopy; Confocal Microscopy; Implementation of synchotron X-ray microscopy for investigations of the cellular uptake and cellular metabolism of metallointercalators; Biomolecular Helical Structure; Viscosity, TGA and Dialysis; Microarrays; Cytotoxicity-Cell lines; Antibacterical activity; Animal testing.
520 _aA comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.
650 0 _aChemistry.
650 0 _aSpectroscopy.
650 0 _aChemistry, inorganic.
650 0 _aChemistry, Physical organic.
650 0 _aPharmacy.
650 0 _aBiochemistry.
650 1 4 _aChemistry.
650 2 4 _aInorganic Chemistry.
650 2 4 _aPharmacy.
650 2 4 _aBiochemistry, general.
650 2 4 _aPhysical Chemistry.
650 2 4 _aSpectroscopy/Spectrometry.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783211094273
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-211-99079-7
912 _aZDB-2-CMS
999 _c106612
_d106612