000 03257nam a22004455i 4500
001 978-1-60761-993-2
003 DE-He213
005 20140220083735.0
007 cr nn 008mamaa
008 130623s2011 xxu| s |||| 0|eng d
020 _a9781607619932
_9978-1-60761-993-2
024 7 _a10.1007/978-1-60761-993-2
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
100 1 _aPasternak, Gavril W.
_eeditor.
245 1 4 _aThe Opiate Receptors
_h[electronic resource] /
_cedited by Gavril W. Pasternak.
250 _a2.
264 1 _aTotowa, NJ :
_bHumana Press :
_bImprint: Humana Press,
_c2011.
300 _aXII, 516 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aThe Receptors
505 0 _aYou’ve Come a Long Way Baby -- The evolution of concepts of opioid receptors -- Pharmacology of opioid drugs -- Opioid receptors: the early years -- Endogenous opioids -- Molecular biology of mu opioid receptors -- Delta Opioid Receptors -- Kappa opioid receptor gene and the regulatory mechanisms of its protein expression -- Opioid receptor signal transduction mechanisms -- Mu opioid receptor mediated analgesia and reward -- Kappa opioid receptor function -- Delta opioid receptor function -- Genetics of opioid receptor functions in mice -- Opioid receptor trafficking -- Opioid receptor dimerization -- Molecular modulation of in vivo tolerance -- Genetics of opioid actions.
520 _aIn 1988, Gavril W. Pasternak published the first edition of this seminal text. It was a lucid account of the latest knowledge on opiate receptors and related receptor subtypes, a then controversial field, providing an integrated approach correlating the biochemical, physiological, and pharmacological aspects of opiate reaction. Fully revised and expanded, The Opiate Receptors, 2nd edition presents all the advances made in the field in the past twenty years. It covers a wide variety of topics including, but not limited to, the following: pharmacology of opioid drugs; endogenous opioids; molecular biology of mu receptors; molecular biology of delta receptors; kappa opioid receptor gene and the regulatory mechanisms of its protein expression; opioid receptor signal transduction mechanisms; mu opioid receptor mediated analgesia and reward; kappa opioid receptor function; delta opioid receptor function; genetics of opioid receptor functions in mice; opioid receptor trafficking; opioid receptor dimerization; molecular modulation of in vivo tolerance; and genetics of opioid actions. Written by leading international researchers in the field, this new edition is as groundbreaking and vital as its predecessor.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781607619925
830 0 _aThe Receptors
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-60761-993-2
912 _aZDB-2-SBL
999 _c106383
_d106383