000 04003nam a22004575i 4500
001 978-1-60761-478-4
003 DE-He213
005 20140220083735.0
007 cr nn 008mamaa
008 110601s2011 xxu| s |||| 0|eng d
020 _a9781607614784
_9978-1-60761-478-4
024 7 _a10.1007/978-1-60761-478-4
_2doi
050 4 _aRC254-282
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a616.994
_223
100 1 _aGioeli, Daniel.
_eeditor.
245 1 0 _aTargeted Therapies
_h[electronic resource] :
_bMechanisms of Resistance /
_cedited by Daniel Gioeli.
264 1 _aTotowa, NJ :
_bHumana Press,
_c2011.
300 _aXIV, 202 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMolecular and Translational Medicine
505 0 _aResistance to Targeted Therapies As a Result of Mutation(s) in the Target.- The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies.- Cancer Signaling Network Analysis by Quantitative Mass Spectrometry.-  Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications.-  Using Phosphoflow to Study Signaling Events of Sub Populations Resistant to Current Therapies -- Mathematical and Computational Models in Cancer -- Somatic Evolution of Acquired Drug Resistance in Cancer -- Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance Mathematical and Computational Models in Cancer -- Somatic Evolution of Acquired Drug Resistance in Cancer -- Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance Mathematical and Computational Models in Cancer -- Somatic Evolution of Acquired Drug Resistance in Cancer -- Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance.
520 _aThis volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included.  Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.
650 0 _aMedicine.
650 0 _aOncology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aOncology.
650 2 4 _aMolecular Medicine.
650 2 4 _aCancer Research.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781607614777
830 0 _aMolecular and Translational Medicine
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-60761-478-4
912 _aZDB-2-SME
999 _c106363
_d106363