000 03165nam a22004575i 4500
001 978-1-4419-9911-5
003 DE-He213
005 20140220083731.0
007 cr nn 008mamaa
008 110812s2011 xxu| s |||| 0|eng d
020 _a9781441999115
_9978-1-4419-9911-5
024 7 _a10.1007/978-1-4419-9911-5
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aFantus, I. George.
_eeditor.
245 1 0 _aInsulin Resistance and Cancer
_h[electronic resource] :
_bEpidemiology, Cellular and Molecular Mechanisms and Clinical Implications /
_cedited by I. George Fantus.
264 1 _aNew York, NY :
_bSpringer New York,
_c2011.
300 _aXII, 300 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aEnergy Balance and Cancer ;
_v1
505 0 _aInsulin and the Physiology of Carbohydrate and Lipid Metabolism -- Insulin Signalling: Cellular and Molecular Mechanisms -- Mechanisms of Insulin Resistance, Obesity and Metabolic Syndrome -- Obesity and Cancer: Epidemiology -- Insulin, Insulin Resistance and Cancer Associations -- Animal Models of Hyperinsulinemia, Insulin Resistance and Cancer -- Actions of Insulin as a Survival and Growth Factor: Akt/PKB, mTOR and MAPK Signaling -- Potential Mechanisms Linking Insulin to Cancer -- Insulin-like Growth Factors and Cancer -- Insulin, IGF Receptors and Cancer -- Clinical Implications for Cancer Treatment and Prevention.
520 _aThis book reviews the epidemiological associations between insulin resistance and cancer. This is followed by reviews of animal models which support this relationship and provide insight into potential mechanisms. Several chapters then provide detailed examination of the cellular and molecular changes characterizing the insulin resistant state, such as hyperinsulinemia, abnormal metabolism and hormone signaling, and how these interact with various tumor characteristics. For example some tumors present increased quantities of the fetal form of the insulin receptor, unique regulation of oxidative (Krebs’ cycle) metabolism (Warburg effect), as well as mutations in various relevant signaling pathways. Finally, the clinical implications of these data are integrated with considerations of insulin “sensitization” and potential metabolic interventions to prevent and treat cancer. It should be noted that while a number of cancers are associated with obesity the authors here have focused primarily on breast cancer as a key and significant model.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aPharmacology/Toxicology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441999108
830 0 _aEnergy Balance and Cancer ;
_v1
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-9911-5
912 _aZDB-2-SME
999 _c106154
_d106154