000			03573nam a22004695i 4500
001			978-1-4419-7656-7
003			DE-He213
005			20140220083724.0
007			cr nn 008mamaa
008			101118s2011 xxu| s |||| 0|eng d
020			_a9781441976567 _9978-1-4419-7656-7
024	7		_a10.1007/978-1-4419-7656-7 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aDupuy, Adam J. _eeditor.
245	1	0	_aInsertional Mutagenesis Strategies in Cancer Genetics _h[electronic resource] / _cedited by Adam J. Dupuy, David A. Largaespada.
264		1	_aNew York, NY : _bSpringer New York, _c2011.
300			_aVIII, 200p. 18 illus., 4 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aChapter 1: Introduction: Author: Anton Berns (Netherlands Cancer Institute) -- Chapter 2: Retroviral mutagenesis in mouse leukemia/lymphoma: Author: David Largaespada, Ph.D. (University of Minnesota) -- Chapter 3: MMTV models of breast cancer: Author: John Hilkens (NKI) -- Chapter 4: Retroviral mutagenesis in other organisms: Author: Michael Dvorak (Inst. Of Molecular Genetics, Prague, Czech Rep.) -- Chapter 5: Sleeping Beauty models of cancer: Author: Adam J. Dupuy, Ph.D. (University of Iowa) -- Chapter 6: Insertional mutagenesis in gene therapy patients: Author: David Williams, M.D. (Cincinnati Children’s Hospital) -- Chapter 7: Bioinformatics of high throughput insertional mutagenesis: Author: Keiko Akagi (NCI-Frederick).
520			_aOver the past decades, insertional mutagenesis has played an important contribution to our understanding of cancer. Initially, the action of slow transforming retroviruses was used to identify endogenous cellular oncogenes (e.g. Myc, Myb). These observations sparked a series of experiments that eventually led to the idea cancer is caused by somatically acquired mutations in endogenous oncogenes and tumor suppressor genes. Since these discoveries, insertional mutagenesis has been used to identify novel cancer genes in a variety of tumor types in animal models of cancer. More recent work has developed novel insertional mutagens, such as transposons, that have broader capabilities to model cancer in vivo. While this work has focused on developing animal models of cancer, recent gene therapy trials in human patients have shown that insertional mutagenesis can also contribute to transformation. The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aHuman genetics.
650		0	_aToxicology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aHuman Genetics.
650	2	4	_aPharmacology/Toxicology.
700	1		_aLargaespada, David A. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441976550
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4419-7656-7
912			_aZDB-2-SBL
999			_c105824 _d105824