000			04226nam a22004455i 4500
001			978-1-4419-6787-9
003			DE-He213
005			20140220083721.0
007			cr nn 008mamaa
008			110204s2011 xxu| s |||| 0|eng d
020			_a9781441967879 _9978-1-4419-6787-9
024	7		_a10.1007/978-1-4419-6787-9 _2doi
050		4	_aRC321-580
072		7	_aPSAN _2bicssc
072		7	_aMED057000 _2bisacsh
082	0	4	_a612.8 _223
100	1		_aNixon, Ralph A. _eeditor.
245	1	0	_aCytoskeleton of the Nervous System _h[electronic resource] / _cedited by Ralph A. Nixon, Aidong Yuan.
264		1	_aNew York, NY : _bSpringer New York, _c2011.
300			_aXV, 774p. 117 illus., 56 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Neurobiology, _x2190-5215 ; _v3
505	0		_aCentral Axonal Development and Pathology in Early Life -- Microtubules in the nervous system -- Tau phosphorylation -- Tau Pathology -- Tauopathy and brain aging -- Microtubule-associated protein 4 -- Structure of Neural Intermediate Filaments -- Alpha-internexin: the Fourth Subunit of Neurofilaments in the Mature CNS -- Peripherin Pathology -- Neurofilament cross-bridge: a structure associated specifically with the neurofilament among the intermediate filament family -- Neurofilament Transport -- Knockout models of neurofilament proteins -- Neurofilaments and Radial Growth: Deconstruction of a hypothesis through the construction of gene targeted mice -- Deregulation of Cytoskeletal Protein Phosphorylation and Neurodegeneration -- Neurofilaments in Aged Animals -- Neurofilament changes in Multiple Sclerosis -- Intermediate filament interactions in neurons -- Tropomyosins in Neuronal Morphogenesis and Development -- The Driving Machinery for Growth Cone Navigation -- Glial Fibrillary Acidic Protein: The intermediate filament protein of astrocytes -- Axonal Transport Mechanisms in Cytoskeleton Formation and Regulation -- Axonal transport and motor neuron disease -- In vivo imaging of axonal transport in aging and Alzheimer's disease -- Regulation of Cytoskeletal Composition in Neurons: Transcriptional and Post-transcriptional Control in Development, Regeneration, and Disease -- Crosstalks between myelinating cells and the axonal cytoskeleton -- Topographic regulation of neuronal intermediate filament proteins by phosphorylation: In health and disease -- Cytoskeleton, axonal transport, and the mechanisms of axonal neuropathy -- Effects of Insulin on Tau and Neurofilament -- Ethanol effects on the cytoskeleton of nerve tissue cells.
520			_aWithout a cytoskeleton, a neuron or glial cell would be a shapeless jelly mass unable to function in the milieu of the brain. If we are to understand neuronal cells function in health and disease, we must determine how the cytoskeleton forms and contributes to neural physiology and pathobiology. Cytoskeleton of the Nervous System provides a comprehensive, authoritative and up-to-date account of what we now know and what we want to know in the near future--about the functioning of the cytoskeleton of neuronal cells at the molecular level. In lively accounts, which are unafraid to address controversy, Cytoskeleton of the Nervous System introduces readers to the most sophisticated concepts and latest discoveries: from overexpression systems to knock-out models for specific cytoskeletal proteins, from continuous transport assays in vivo to live-cell imaging in primary neurons, and from factors regulating cytoskeleton behavior to the dysregulation of these processes leading to neurological disease.
650		0	_aMedicine.
650		0	_aNeurosciences.
650	1	4	_aBiomedicine.
650	2	4	_aNeurosciences.
700	1		_aYuan, Aidong. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441967862
830		0	_aAdvances in Neurobiology, _x2190-5215 ; _v3
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4419-6787-9
912			_aZDB-2-SBL
999			_c105639 _d105639