000			03145nam a22004815i 4500
001			978-1-4419-5629-3
003			DE-He213
005			20140220083720.0
007			cr nn 008mamaa
008			110406s2011 xxu| s |||| 0|eng d
020			_a9781441956293 _9978-1-4419-5629-3
024	7		_a10.1007/978-1-4419-5629-3 _2doi
050		4	_aRM1-950
072		7	_aMMG _2bicssc
072		7	_aMED071000 _2bisacsh
082	0	4	_a615 _223
100	1		_aKhojasteh, Siamak Cyrus. _eauthor.
245	1	0	_aDrug Metabolism and Pharmacokinetics Quick Guide _h[electronic resource] / _cby Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E.C.A. Hop.
264		1	_aNew York, NY : _bSpringer New York, _c2011.
300			_aXIII, 214 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPharmacokinetics -- Drug Metabolizing Enzymes -- Oral Absorption -- Transporters -- Metabolism-Based Drug Interactions -- Biotransformation and Bioactivation -- Prediction of Human Pharmacokinetics -- Advances in Bioanalysis as it Relates to ADME -- ADME Properties and Their Dependence on Physicochemical Properties -- In Silico ADME Tools -- Approved Drugs -- Chemical Nomenclature.
520			_aDrug Metabolism and Pharmacokinetics Quick Guide is intended for broad readership of those interested in the discipline of drug metabolism and pharmacokinetics who work in drug discovery coming from the various disciplines, a background such as of medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics or toxicology. This guide provides, for the first time, a completely integrated look at multiple aspects of absorption, distribution, metabolism, and excretion (ADME) science in a summary format that is clear, concise and self-explanatory. This book will be used and referenced frequently as it provides detailed figures and tables for data interpretation. Also included are brief yet relevant factoids that bring a real-world dimension to the discussion of drug metabolism and pharmacokinetics. Key topics covered: 1. Pharmacokinetics 2. Drug metabolizing enzymes 3. Oral absorption 4. Transporters 5. Metabolism-based drug interactions 6. Biotransformation and bioactivation 7. Prediction of human pharmacokinetics 8. Bioanalysis 9. Physicochemical properties and drug-like properties 10. In silico tools 11. Approved drugs 12. Chemical nomenclature
650		0	_aMedicine.
650		0	_aToxicology.
650		0	_aPharmacy.
650		0	_aBiochemistry.
650	1	4	_aBiomedicine.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aPharmacy.
650	2	4	_aBiochemistry, general.
700	1		_aWong, Harvey. _eauthor.
700	1		_aHop, Cornelis E.C.A. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441956286
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4419-5629-3
912			_aZDB-2-SBL
999			_c105554 _d105554