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001 978-1-4419-1607-5
003 DE-He213
005 20140220083719.0
007 cr nn 008mamaa
008 101116s2011 xxu| s |||| 0|eng d
020 _a9781441916075
_9978-1-4419-1607-5
024 7 _a10.1007/978-1-4419-1607-5
_2doi
050 4 _aRC648-665.2
072 7 _aMJG
_2bicssc
072 7 _aMED027000
_2bisacsh
082 0 4 _a616.4
_223
100 1 _aAhima, Rexford S.
_eeditor.
245 1 0 _aMetabolic Basis of Obesity
_h[electronic resource] /
_cedited by Rexford S. Ahima.
264 1 _aNew York, NY :
_bSpringer New York,
_c2011.
300 _aXIV, 391p. 47 illus., 28 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _a1. Principles of human energy metabolism -- 2. Intermediary metabolism of carbohydrate, protein and fat -- 3. Adipose tissue development, structure, function -- 4. Adipokines in health and disease -- 5. Neural control of feeding and energy homeostasis -- 6. Gastrointestinal hormones and obesity -- 7. Genes and human obesity -- 8. Classical hormones linked to obesity -- 9. Inflammation and adipose dysfunction -- 10. Insulin resistance in the metabolic syndrome -- 11. Pancreatic islet b-cell function in obesity -- 12. Non-alcoholic fatty liver disease and the metabolic syndrome -- 13. Sleep, circadian rhythms and metabolism -- 14. Obesity and cardiac dysfunction -- 15. Atherogenic lipid metabolism in obesity -- 16. Gut microbes, immunity and metabolism -- 17. Impact of obesity on female reproductive health -- 18. Lessons from HIV lipodystrophy and drug-induced metabolic dysfunction -- 19. Principles of obesity therapy.
520 _aThe obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aNeurosciences.
650 0 _aEndocrinology.
650 0 _aGastroenterology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aEndocrinology.
650 2 4 _aGastroenterology.
650 2 4 _aNeurosciences.
650 2 4 _aHuman Physiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441916068
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-1607-5
912 _aZDB-2-SME
999 _c105540
_d105540