000 04167nam a22004215i 4500
001 978-94-007-5025-8
003 DE-He213
005 20140220083347.0
007 cr nn 008mamaa
008 121026s2012 ne | s |||| 0|eng d
020 _a9789400750258
_9978-94-007-5025-8
024 7 _a10.1007/978-94-007-5025-8
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aFALASCA, MARCO.
_eeditor.
245 1 0 _aPhosphoinositides and Disease
_h[electronic resource] /
_cedited by MARCO FALASCA.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2012.
300 _aVI, 318 p. 28 illus., 13 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v362
505 0 _aTable of contents -- An introduction to Phosphoinositides, Tania Maffucci -- Phosphoinositides and Cardiovascular Diseases, Emilio Hirsch -- Phosphoinositides in Insulin Action and Diabetes, Alan Saltiel -- Phosphoinositides in neuroexocytosis and neuronal diseases, Frederic Meunier -- Effects of Phosphoinositides and their derivatives on Membrane Morphology and function,  Banafshe Larijani -- Molecular analysis of protein-phosphoinositide interactions, Tatiana Kutateladze -- PIKfyve and its lipid products in health and in sickness,  Assia Shisheva -- Class I phosphoinositide 3-kinases in normal and pathologic haematopoietic cells, Bernard Payrastre -- The diverse functions of Phosphatidylinositol Transfer proteins, Shamshad Cockcroft -- Myotubularin phosphoinositide phosphatases in human diseases, Jocelyn Laporte -- Nuclear PI-PLC β1 and Myelodysplastic Syndromes: from bench to clinics, Lucio Cocco -- Inositol polyphosphate phosphatases in human disease, Christina Mitchell -- Index.
520 _aPhosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field  and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.
650 0 _aMedicine.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400750241
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v362
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-5025-8
912 _aZDB-2-SBL
999 _c104836
_d104836