000			03743nam a22004455i 4500
001			978-94-007-4917-7
003			DE-He213
005			20140220083347.0
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008			120827s2012 ne | s |||| 0|eng d
020			_a9789400749177 _9978-94-007-4917-7
024	7		_a10.1007/978-94-007-4917-7 _2doi
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072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aChen, George G. _eeditor.
245	1	0	_aNovel Apoptotic Regulators in Carcinogenesis _h[electronic resource] / _cedited by George G. Chen, Paul B.S. Lai.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2012.
300			_aXI, 299 p. 84 illus., 18 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPreface.-1 Apoptosis Inducer from Streblus asper Extracts for Cancer Chemoprevention -- 2 Apoptosis Induction by Nimbolide, a Limonoid from Azadirachta indica: Molecular Targets and Signaling Networks -- 3 Heterocyclics as inducers of apoptosis -- 4 Anthocyanins as Apoptotic Agents -- 5 Apoptosis as a mechanism involved in the anticancer effect of dietary n-3 polyunsaturated fatty acids -- 6 Apoptotic Pathways Upon Arsenite Treatment -- 7 Flavokawains in Cancer Prevention and Treatment: Potentials and Challenges -- 8 Progesterone Receptor Modulators Induce Apoptosis in Mammary Tumors and Uterine Leiomyomas -- 9 Apoptotic regulators and its clinical implication in mammary carcinoma -- 10 Curcumin analogs as inhibitors of the Jak-STAT signal transduction pathway -- 11 Targeting cancer by betulin and betulinic acid. Abbreviations. Subject index.
520			_aOur recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically synthesized. While we are excited about the discovery and development of these novel apoptotic regulators as potential anticancer agents, a degree of caution should be always borne in mind when interpreting the success of preclinical pro-apoptotic candidates since potential problems inevitably lie ahead. These problems usually include target specificity, unanticipated toxicity, compound stability, formulation issues, pharmacokinetic and pharmacodynamic profiles. Nevertheless, we believe that this collection of 11 chapters by established leaders in the area of apoptosis will be of great interest to not only academics working in the field of cancer research and apoptosis but also pharmaceutical and pharmacological industries that . We are looking forward to the further development to push these potential agents toward clinical stage.
650		0	_aMedicine.
650		0	_aEntomology.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aMedicine/Public Health, general.
650	2	4	_aEntomology.
700	1		_aLai, Paul B.S. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400749160
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-4917-7
912			_aZDB-2-SBL
999			_c104829 _d104829