000 | 02794nam a22005055i 4500 | ||
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001 | 978-94-007-4572-8 | ||
003 | DE-He213 | ||
005 | 20140220083347.0 | ||
007 | cr nn 008mamaa | ||
008 | 120823s2012 ne | s |||| 0|eng d | ||
020 |
_a9789400745728 _9978-94-007-4572-8 |
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024 | 7 |
_a10.1007/978-94-007-4572-8 _2doi |
|
050 | 4 | _aR-RZ | |
072 | 7 |
_aMBGR _2bicssc |
|
072 | 7 |
_aMED000000 _2bisacsh |
|
082 | 0 | 4 |
_a610 _223 |
100 | 1 |
_aMacNeill, Stuart. _eeditor. |
|
245 | 1 | 4 |
_aThe Eukaryotic Replisome: a Guide to Protein Structure and Function _h[electronic resource] / _cedited by Stuart MacNeill. |
264 | 1 |
_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2012. |
|
300 |
_aVIII, 345 p. 69 illus., 56 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
||
338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
||
490 | 1 |
_aSubcellular Biochemistry, _x0306-0225 ; _v62 |
|
520 | _aSuccessful chromosome replication is vital for maintaining the integrity of the genetic material in all forms of cellular life. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Inspired by recent exciting breakthroughs in protein structure determination and written by leading experts in the field, The Eukaryotic Replisome: a guide to protein structure and function takes the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosomal DNA replication, from replication origin recognition and the assembly of the pre-replicative complexes in G1 through to the final processing of Okazaki fragments at the end of S-phase. This extensively illustrated book is an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aOncology. | |
650 | 0 | _aBiochemistry. | |
650 | 0 | _aNucleic acids. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aBiomedicine general. |
650 | 2 | 4 | _aBiochemistry, general. |
650 | 2 | 4 | _aProtein Science. |
650 | 2 | 4 | _aProtein Structure. |
650 | 2 | 4 | _aNucleic Acid Chemistry. |
650 | 2 | 4 | _aCancer Research. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9789400745711 |
830 | 0 |
_aSubcellular Biochemistry, _x0306-0225 ; _v62 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-94-007-4572-8 |
912 | _aZDB-2-SBL | ||
999 |
_c104790 _d104790 |