000 02794nam a22005055i 4500
001 978-94-007-4572-8
003 DE-He213
005 20140220083347.0
007 cr nn 008mamaa
008 120823s2012 ne | s |||| 0|eng d
020 _a9789400745728
_9978-94-007-4572-8
024 7 _a10.1007/978-94-007-4572-8
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aMacNeill, Stuart.
_eeditor.
245 1 4 _aThe Eukaryotic Replisome: a Guide to Protein Structure and Function
_h[electronic resource] /
_cedited by Stuart MacNeill.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2012.
300 _aVIII, 345 p. 69 illus., 56 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSubcellular Biochemistry,
_x0306-0225 ;
_v62
520 _aSuccessful chromosome replication is vital for maintaining the integrity of the genetic material in all forms of cellular life. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Inspired by recent exciting breakthroughs in protein structure determination and written by leading experts in the field, The Eukaryotic Replisome: a guide to protein structure and function takes the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosomal DNA replication, from replication origin recognition and the assembly of the pre-replicative complexes in G1 through to the final processing of Okazaki fragments at the end of S-phase. This extensively illustrated book is an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aBiochemistry.
650 0 _aNucleic acids.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aBiochemistry, general.
650 2 4 _aProtein Science.
650 2 4 _aProtein Structure.
650 2 4 _aNucleic Acid Chemistry.
650 2 4 _aCancer Research.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400745711
830 0 _aSubcellular Biochemistry,
_x0306-0225 ;
_v62
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-4572-8
912 _aZDB-2-SBL
999 _c104790
_d104790