000 04359nam a22005535i 4500
001 978-94-007-4534-6
003 DE-He213
005 20140220083346.0
007 cr nn 008mamaa
008 120614s2012 ne | s |||| 0|eng d
020 _a9789400745346
_9978-94-007-4534-6
024 7 _a10.1007/978-94-007-4534-6
_2doi
050 4 _aQP110.G45
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
072 7 _aSCI029000
_2bisacsh
082 0 4 _a611.01816
_223
100 1 _aWittmann, Christoph.
_eeditor.
245 1 0 _aSystems Metabolic Engineering
_h[electronic resource] /
_cedited by Christoph Wittmann, Sang Yup Lee.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2012.
300 _aXII, 387 p. 76 illus., 41 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface, Christoph Wittmann, Sang Yup Lee -- 1. Genome-scale network modeling, Sang Yup Lee et al -- 2. Kinetic modeling of metabolic networks, Daniel C. Zielinski and Bernhard O. Palsson -- 3. Design of superior cell factories based on systems wide omics analysis, Hiroshi Shimizu et al -- 4. Technologies for bio-systems engineering, Sven Panke et al -- 5. Systems metabolic engineering of Escherichia coli for chemicals, materials, biofuels, and pharmaceuticals, Sang Yup Lee et al -- 6. Systems metabolic engineering of Corynebacterium glutamicum for biobased production of chemicals, materials and fuels, Judith Becker, Stefanie Kind, Christoph Wittmann -- 7. Towards a synthetic biology of the stress-response and the tolerance phenotype: systems understanding and engineering of the Clostridium acetobutylicum stress-response and tolerance to toxic metabolites, Eleftherios T. Papoutsakis, Keith V. Alsaker -- 8. Model-based design of superior cell factory: an illustrative example of Penicillium chrysogenum, I. Emrah Nikerel -- 9. Bridging Omics Technologies with Synthetic Biology in Yeast Industrial Biotechnology, António Roldão, Il-Kwon Kim, Jens Nielsen -- 10. Design of superior cell factories for a sustainable biorefinery by synthetic bioengineering, Tomohisa Hasunuma, Fumio Matsuda, Akihiko Kondo -- 11. Systems-level analysis of cancer metabolism, Paulo A. Gameiro, Christian M. Metallo, Gregory Stephanopoulos -- Index.
520 _aSystems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production.   Integrating systems biology and biotechnology with new concepts from synthetic biology, it enables the global analysis and engineering of microorganisms – and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundament to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter into this exiting field.
650 0 _aMedicine.
650 0 _aGene expression.
650 0 _aBiotechnology.
650 0 _aGenetic engineering.
650 0 _aBioinformatics.
650 0 _aBiological models.
650 0 _aMicrobial genetics.
650 1 4 _aBiomedicine.
650 2 4 _aGene Expression.
650 2 4 _aSystems Biology.
650 2 4 _aBiotechnology.
650 2 4 _aMicrobial Genetics and Genomics.
650 2 4 _aGenetic Engineering.
650 2 4 _aComputational Biology/Bioinformatics.
700 1 _aLee, Sang Yup.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400745339
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-4534-6
912 _aZDB-2-SBL
999 _c104783
_d104783