000			03094nam a22004815i 4500
001			978-94-007-4351-9
003			DE-He213
005			20140220083346.0
007			cr nn 008mamaa
008			120813s2012 ne | s |||| 0|eng d
020			_a9789400743519 _9978-94-007-4351-9
024	7		_a10.1007/978-94-007-4351-9 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aAgostinis, Patrizia. _eeditor.
245	1	0	_aEndoplasmic Reticulum Stress in Health and Disease _h[electronic resource] / _cedited by Patrizia Agostinis, Samali Afshin.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2012.
300			_aVIII, 452 p. 48 illus., 40 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
520			_aThe Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome.  This book primarily focuses on the pathophysiology of ER stress.  It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and  metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit.  Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.
650		0	_aMedicine.
650		0	_aImmunology.
650		0	_aCytology.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aMolecular Medicine.
650	2	4	_aCell Biology.
650	2	4	_aApoptosis.
650	2	4	_aCell Physiology.
650	2	4	_aImmunology.
700	1		_aAfshin, Samali. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400743502
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-4351-9
912			_aZDB-2-SBL
999			_c104758 _d104758