000 02621nam a22005055i 4500
001 978-94-007-4216-1
003 DE-He213
005 20140220083346.0
007 cr nn 008mamaa
008 120404s2012 ne | s |||| 0|eng d
020 _a9789400742161
_9978-94-007-4216-1
024 7 _a10.1007/978-94-007-4216-1
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aBerencsi III, György.
_eeditor.
245 1 0 _aMaternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis
_h[electronic resource] /
_cedited by György Berencsi III.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2012.
300 _aVIII, 464p. 18 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
520 _aThe human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes. The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy. The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aImmunology.
650 0 _aMedical virology.
650 0 _aPediatrics.
650 0 _aEpidemiology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aVirology.
650 2 4 _aImmunology.
650 2 4 _aOncology.
650 2 4 _aPediatrics.
650 2 4 _aEpidemiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400742154
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-4216-1
912 _aZDB-2-SBL
999 _c104735
_d104735