000			03202nam a22005055i 4500
001			978-94-007-2849-3
003			DE-He213
005			20140220083343.0
007			cr nn 008mamaa
008			120103s2012 ne | s |||| 0|eng d
020			_a9789400728493 _9978-94-007-2849-3
024	7		_a10.1007/978-94-007-2849-3 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aProkop, Aleš. _eauthor.
245	1	0	_aSystems Biology in Biotech & Pharma _h[electronic resource] : _bA Changing Paradigm / _cby Aleš Prokop, Seth Michelson.
264		1	_aDordrecht : _bSpringer Netherlands, _c2012.
300			_aXVIII, 127p. 16 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSpringerBriefs in Pharmaceutical Science & Drug Development, _x1864-8118 ; _v2
505	0		_aAbstract -- 1 Introduction: Discovery & Development - New Facet Of Industry, New Tools And Lead Optimization: 1.1 Scope And Content Of This Review -- 2 Discovery: Use Of Systems Biology For Identifying Targets -- 3 Integrative Systems Biology I - Biochemistry:  Phase I Lead Discovery & Molecular Interactions -- 4 Integrative Systems Biology Ii - Molecular Biology:  Phase 2 Lead Discovery & In Silico Screening -- 5. Discovery: Computational Systems Biology (Csb) In Health & And Disease I -- 6 Development:  In Vivo Pharmacology - Systems Biology In Health & Disease Ii -- 7 Development: Pharmacokinetics – Systems Biology In Health & Disease Iii -- 8 Development:  Multiscale Csb – Simulation Tools -- 9 Development:  Drug Formulation & Delivery -- 10 Development: Preclinical Model Based Drug Development -- 11 Systems Biology: Impact On Pharma And Biotech -- 12 Acknowledgment -- 13 Bibliography.
520			_aSystems Biology (SB) is a suite of technologies and methodologies that resulted, conceptually from the merging of two basic paradigms, reductionism and holism. It represents a combination of reductionist and holistic approaches to the relationships among the elements of a system, with the goal of identifying its emergent properties and defining, quantitatively, molecular, cellular, tissue, organ and whole body processes. One manifestation of SB is as a tool for hypothesis generation about a system that is typically too large and complex to understand by simple reasoning.
650		0	_aMedicine.
650		0	_aPharmaceutical technology.
650		0	_aBiotechnology.
650		0	_aMicrobiology.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aBiotechnology.
650	2	4	_aApplied Microbiology.
650	2	4	_aPharmaceutical Sciences/Technology.
700	1		_aMichelson, Seth. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400728486
830		0	_aSpringerBriefs in Pharmaceutical Science & Drug Development, _x1864-8118 ; _v2
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-2849-3
912			_aZDB-2-SME
999			_c104588 _d104588