000 04016nam a22005415i 4500
001 978-94-007-2561-4
003 DE-He213
005 20140220083342.0
007 cr nn 008mamaa
008 111117s2012 ne | s |||| 0|eng d
020 _a9789400725614
_9978-94-007-2561-4
024 7 _a10.1007/978-94-007-2561-4
_2doi
050 4 _aQH301-705
072 7 _aPSA
_2bicssc
072 7 _aSCI086000
_2bisacsh
082 0 4 _a570
_223
100 1 _aBreitenbach, Michael.
_eeditor.
245 1 0 _aAging Research in Yeast
_h[electronic resource] /
_cedited by Michael Breitenbach, S. Michal Jazwinski, Peter Laun.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2012.
300 _aXII, 368 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSubcellular Biochemistry,
_x0306-0225 ;
_v57
505 0 _a1. Preface and Introduction to Aging research in Yeast -- 2.Oxidative stresses and ageing -- 3.The role of Mitochondria in the aging processes of yeast -- 4.The Retrograde Response and Other Pathways of Interorganelle Communication in Yeast Replicative Aging -- 5. Chronological Aging in Saccharomyces cerevisiae -- 6. Still waters run deep: Aging and the survival of quiescent and non-quiescent cells in yeast stationary-phase cultures -- 7. Maximising the yeast chronological lifespan -- 8.Amino Acid Homeostasis and Chronological Longevity in Saccharomyces cerevisiae -- 9. DNA damage and DNA replication stress in yeast models of aging -- 10.Yeast aging and apoptosis.-11. Cellular homeostasis in fungi: Impact on the aging process -- 12.Genome-wide analysis of yeast aging -- 13. Genetic Approaches to Aging in Budding and Fission Yeasts: New Connections and New Opportunities -- 14. Evolution of asymmetric damage segregation: a modelling approach.-15. Cellular ageing and the actin cytoskeleton.
520 _aThis volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.
650 0 _aLife sciences.
650 0 _aGeriatrics.
650 0 _aCytology.
650 0 _aMicrobiology.
650 1 4 _aLife Sciences.
650 2 4 _aLife Sciences, general.
650 2 4 _aGeriatrics/Gerontology.
650 2 4 _aCell Biology.
650 2 4 _aApoptosis.
650 2 4 _aOxidative Stress.
650 2 4 _aMicrobiology.
700 1 _aJazwinski, S. Michal.
_eeditor.
700 1 _aLaun, Peter.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400725607
830 0 _aSubcellular Biochemistry,
_x0306-0225 ;
_v57
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-2561-4
912 _aZDB-2-SBL
999 _c104514
_d104514