000 03770nam a22004935i 4500
001 978-94-007-2558-4
003 DE-He213
005 20140220083342.0
007 cr nn 008mamaa
008 120101s2012 ne | s |||| 0|eng d
020 _a9789400725584
_9978-94-007-2558-4
024 7 _a10.1007/978-94-007-2558-4
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aFatatis, Alessandro.
_eeditor.
245 1 0 _aSignaling Pathways and Molecular Mediators in Metastasis
_h[electronic resource] /
_cedited by Alessandro Fatatis.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2012.
300 _aX, 375p. 148 illus., 49 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface.-1. Introduction.I. Local invasion.-2. Reactivation of Epithelial Mesenchymal Transition in Invasive and Metastatic Cancer.-3. Biomechanical ECM Switches and Tumor Metastasis.-4. Moving aggressively: S100A4 and Tumor Invasion -- 5. Shift in TGF-b-induced signaling as culprit for local invasion and dissemination.-6. Role of Rac1-GEF and Dock180 in mediating tyrosine-kinase stimulated glioma invasion -- 7. Impact of tumor hypoxia, Src and Met signaling in the dissemination of tumor cells.II. Homing  and colonization at distant sites.-8. Cellular and Molecular Biology of Cancer Cell extravasation -- 9.  Role of CXCL12 and CXCR4 in tumor biology and metastasis.-10. Transcription factors Stat5a/b and Stat3 in prostate cancer growth and metastases.-11. Survival and growth of early metastatic foci in the bone: Role of the alpha-receptor for Platelet-Derived Growth Factor.-12. Androgen receptor in regulation of prostate cancer progression and metastasis -- 13. Integrin signaling in angiogenesis and metastatic progression in the brain.-14. Tumor and host determinants of pulmonary metastasis in bladder cancer.-15. The Influence of metastatic breast cancer on the bone microenvironment. Index.
520 _aThis work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a single source. Finally, an introductory chapter provides a clinical perspective of the problems presented by metastatic tumours for diagnosis and treatment. The work presented here is directed to researchers in tumour biology with a developing interest in metastatic dissemination as well as medical and graduate students seeking to expand and integrate the notions acquired in basic cancer biology and oncology courses.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aMedical genetics.
650 0 _aCell receptors.
650 0 _aCytokines.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aOncology.
650 2 4 _aGene Function.
650 2 4 _aReceptors.
650 2 4 _aCytokines and Growth Factors.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400725577
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-2558-4
912 _aZDB-2-SBL
999 _c104513
_d104513