| 000 | 02717nam a22004455i 4500 | ||
|---|---|---|---|
| 001 | 978-94-007-2495-2 | ||
| 003 | DE-He213 | ||
| 005 | 20140220083341.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 120101s2012 ne | s |||| 0|eng d | ||
| 020 |
_a9789400724952 _9978-94-007-2495-2 |
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| 024 | 7 |
_a10.1007/978-94-007-2495-2 _2doi |
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| 050 | 4 | _aRC261-271 | |
| 072 | 7 |
_aMJCL _2bicssc |
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| 072 | 7 |
_aMED062000 _2bisacsh |
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| 082 | 0 | 4 |
_a614.5999 _223 |
| 100 | 1 |
_aMichels, Karin B. _eeditor. |
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| 245 | 1 | 0 |
_aEpigenetic Epidemiology _h[electronic resource] / _cedited by Karin B. Michels. |
| 264 | 1 |
_aDordrecht : _bSpringer Netherlands, _c2012. |
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| 300 |
_aXII, 439p. 43 illus., 35 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 520 | _aThe exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics! | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aOncology. | |
| 650 | 0 | _aHuman genetics. | |
| 650 | 0 | _aEpidemiology. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aCancer Research. |
| 650 | 2 | 4 | _aEpidemiology. |
| 650 | 2 | 4 | _aHuman Genetics. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9789400724945 |
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-94-007-2495-2 |
| 912 | _aZDB-2-SBL | ||
| 999 |
_c104495 _d104495 |
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