000 04109nam a22005175i 4500
001 978-94-007-2184-5
003 DE-He213
005 20140220083340.0
007 cr nn 008mamaa
008 120101s2012 ne | s |||| 0|eng d
020 _a9789400721845
_9978-94-007-2184-5
024 7 _a10.1007/978-94-007-2184-5
_2doi
050 4 _aQH601-602
050 4 _aQR77
072 7 _aPHVN
_2bicssc
072 7 _aPSF
_2bicssc
072 7 _aSCI009000
_2bisacsh
082 0 4 _a571.64
_223
100 1 _aHélix-Nielsen, Claus.
_eeditor.
245 1 0 _aBiomimetic Membranes for Sensor and Separation Applications
_h[electronic resource] /
_cedited by Claus Hélix-Nielsen.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2012.
300 _aXV, 284p. 104 illus., 75 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aBiological and Medical Physics, Biomedical Engineering,
_x1618-7210
520 _aThis book addresses the possibilities and challenges in mimicking biological membranes and creating membrane-based sensor and separation devices. It covers recent advances in developing biomimetic membranes for technological applications with a focus on the use of integral membrane protein mediated transport. It describes the fundamentals of biosensing as well as separation and shows how the two processes work together in biological systems. The book provides an overview of the current state of the art, points to areas that need further investigation and anticipates future directions in the field. Biomimetics is a truly cross-disciplinary approach and this is exemplified by the challenges in mimicking osmotic processes as they occur in nature using aquaporin protein water channels as central building blocks. In the development of a biomimetic sensor/separation technology, both channel and carrier proteins are important and examples of how these may be reconstituted and controlled in biomimetic membranes are presented. Also new developments in our understanding of the reciprocal coupling between the material properties of the biomimetic matrix and the embedded proteins are discussed.  The basic concepts of membrane barrier properties are introduced and discussed in terms of lipid and polymer based membranes. Once a given protein is reconstituted in its final host biomimetic matrix, its stability needs to be maintained and controlled and the challenges associated with insertion and stabilization of alpha-helical bundle proteins are exemplified with aquaporin and ion channels as well as sodium-potassium ATPase proteins. The concept of multi-scale modeling is introduced and exemplified by the use of molecular dynamics, dissipative particle dynamics, and computational fluid dynamics simulations illustrating the issues involved in developing and describing biomimetic systems in a wide range of time and length scales. Scalability is a general issue for all nano-inspired technology developments and many biomimetic membrane applications require that the device can be used in the macroscopic realm. This challenge is addressed here in the context of fabricating biomimetic components, membrane arrays, and compartmentalized systems together with the challenges related to microfluidic design strategies for biomimetic device developments.
650 0 _aPhysics.
650 0 _aBiochemistry.
650 0 _aBiomedical engineering.
650 0 _aBiomaterials.
650 1 4 _aPhysics.
650 2 4 _aMembranes.
650 2 4 _aBiochemistry, general.
650 2 4 _aBiomaterials.
650 2 4 _aBiomedical Engineering.
650 2 4 _aBiophysics and Biological Physics.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400721838
830 0 _aBiological and Medical Physics, Biomedical Engineering,
_x1618-7210
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-2184-5
912 _aZDB-2-PHA
999 _c104404
_d104404