000 | 03217nam a22005055i 4500 | ||
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001 | 978-94-007-1706-0 | ||
003 | DE-He213 | ||
005 | 20140220083338.0 | ||
007 | cr nn 008mamaa | ||
008 | 110907s2012 ne | s |||| 0|eng d | ||
020 |
_a9789400717060 _9978-94-007-1706-0 |
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024 | 7 |
_a10.1007/978-94-007-1706-0 _2doi |
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050 | 4 | _aRC261-271 | |
072 | 7 |
_aMJCL _2bicssc |
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072 | 7 |
_aMED062000 _2bisacsh |
|
082 | 0 | 4 |
_a614.5999 _223 |
100 | 1 |
_aHayat, M.A. _eeditor. |
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245 | 1 | 0 |
_aTumors of the Central Nervous System, Volume 4 _h[electronic resource] : _bBrain Tumors (Part 2) / _cedited by M.A. Hayat. |
264 | 1 |
_aDordrecht : _bSpringer Netherlands, _c2012. |
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300 |
_aXXVI, 386 p. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aTumors of the Central Nervous System ; _v4 |
|
520 | _aThis volume mainly contains information on the diagnosis, therapy, and prognosis of brain tumors. Insights on the understanding of molecular pathways involved in tumor biology are explained, which should lead to the development of effective drugs. Information on pathways (e.g., hedgehog) facilitates targeted therapies in cancer. Tumor models are also presented, which utilize expression data, pathway sensitivity, and genetic abnormalities, representing targets in cancer. For example, rat model of malignant brain tumors using implantation of doxorubicin with drug eluting beads for delivery is explained. The future of pathway-driven therapies for tumors is summarized. The importance of personalizing cancer care is emphasized. The need for supportive measures for survivors of brain cancer is pointed out, so is the quality of life monitoring. The need of rehabilitation therapy for patients with primary and metastatic brain tumors is also emphasized. Role of MicroRNA in distinguishing primary tumors from metastatic primary tumors is discussed. Advantages and limitations of chemotherapy (e.g., temozolomide and doxorubicin) are discussed. The complexity of tumor to tumor transfer is explained; examples discussed are: brain metastases from breast cancer and brain metastases fro non-small cell lung carcinoma. Identification and characterization of biomarkers, including those for metastatic brain tumors, are presented. Genomic analysis for identifying clinically relevant subtypes of glioblastoma is included. A large number of imaging modalities are detailed to study progression and invasion of gliomas. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aOncology. | |
650 | 0 | _aRadiology, Medical. | |
650 | 0 | _aNeurosurgery. | |
650 | 0 | _aPathology. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aCancer Research. |
650 | 2 | 4 | _aNeuroradiology. |
650 | 2 | 4 | _aNeurosurgery. |
650 | 2 | 4 | _aOncology. |
650 | 2 | 4 | _aPathology. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9789400717053 |
830 | 0 |
_aTumors of the Central Nervous System ; _v4 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-94-007-1706-0 |
912 | _aZDB-2-SBL | ||
999 |
_c104315 _d104315 |