000 04000nam a22004935i 4500
001 978-94-007-1685-8
003 DE-He213
005 20140220083338.0
007 cr nn 008mamaa
008 110829s2012 ne | s |||| 0|eng d
020 _a9789400716858
_9978-94-007-1685-8
024 7 _a10.1007/978-94-007-1685-8
_2doi
050 4 _aRC254-282
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a616.994
_223
100 1 _aLitchman, Charisse.
_eeditor.
245 1 0 _aDesmoid Tumors
_h[electronic resource] /
_cedited by Charisse Litchman.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2012.
300 _aXI, 221p. 50 illus., 21 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _a1. Introduction -- Part I  The identification and treatment of Desmoid Tumors -- 2. Clinical presentation of Desmoid Tumors -- 3.  Pathology of Desmoid Tumors -- 4.  APC/ β-catenin degeneration in Desmoid Tumors: important   implications for diagnosis, prognosis, and therapy -- 5. Imaging Techniques in Desmoid Tumors -- 6. Surgical management of DesmoidTumors -- 7. Systemic Therapy of Desmoid Tumors -- 8.  Radiation Therapy for Desmoid Tumors -- 9.  Interventional Radiology -- Part 2  Special Populations with Desmoid Tumors -- 10. Desmoid Disease in Familial Adenomatous Polyposis -- 11. Desmoid Tumor in Children and Adolescents: The Influence of Age -- Part 3  Considerations for current and future advancement in the search for a cure -- 12.  Microarrays and High-Throughput Sequencing in Desmoid Type Fibromatosis and Scar -- 13. Desmoid Tumors: Are they benign or malignant?- 14. The Role of Advocacy Groups in Rare Tumors such as Desmoid Tumors -- Index.
520 _aDesmoid Tumors (DT), also called Aggressive Fibromatoses, are a rare fibroblastic proliferative disease, with an incidence of 2 to 4 new cases per million people per year. Despite the absence of a metastatic potential, DT cause significant morbidity and at times mortality due to its locally invasive behaviour. The anatomical locations can be abdominal, extra-abdominal (often in the extremities) and intra-abdominal. This book is the first manuscript dedicated entirely to Desmoid Tumors. Written by prominent clinicians, researchers and advocacy group experts, patients and professionals alike will find this to be a comprehensive review. Clinical presentation, imaging guidelines and treatment paradigms are highlighted. Both the sporadic and heredity forms (Familial Adenomatous Polyposis) will be discussed. A thorough discussion on the unique issues in children with DT is included. A portion of the book will address the role of the APC gene, the β-catenin protein and the role of mutations in the genesis of DT. Emerging cutting edge research techniques will be revealed. Also included is a thoughtful discussion on the controversial labelling of Desmoid Tumors as benign and the consequences of such a designation. The role of advocacy groups in supporting research and in promoting awareness of rare diseases such as DT will be outlined. This book will serve as basis to prepare clinicians, researchers and patients to embark on the quest for a cure for Desmoid Tumors.
650 0 _aMedicine.
650 0 _aInterventional radiology.
650 0 _aOncology.
650 0 _aCancer
_xSurgery.
650 0 _aAbdomen
_xSurgery.
650 1 4 _aMedicine & Public Health.
650 2 4 _aOncology.
650 2 4 _aSurgical Oncology.
650 2 4 _aInterventional Radiology.
650 2 4 _aAbdominal Surgery.
650 2 4 _aBiomedicine general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400716841
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-1685-8
912 _aZDB-2-SME
999 _c104313
_d104313