000 04323nam a22004935i 4500
001 978-3-642-31334-9
003 DE-He213
005 20140220083321.0
007 cr nn 008mamaa
008 121116s2012 gw | s |||| 0|eng d
020 _a9783642313349
_9978-3-642-31334-9
024 7 _a10.1007/978-3-642-31334-9
_2doi
050 4 _aRM845-862.5
072 7 _aMJCL1
_2bicssc
072 7 _aMED080000
_2bisacsh
082 0 4 _a615.842
_223
100 1 _aSauerwein, Wolfgang.
_eeditor.
245 1 0 _aNeutron Capture Therapy
_h[electronic resource] :
_bPrinciples and Applications /
_cedited by Wolfgang Sauerwein, Andrea Wittig, Raymond Moss, Yoshinobu Nakagawa.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2012.
300 _aIX, 553 p. 157 illus., 84 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPart I: Neutron sources: Fission Reactor Based Irradiation Facilities for Neutron Capture Therapy -- Accelerator-Based BNCT -- Compact Neutron Generator for BNCT -- Californium-252 as a neutron source for BNCT -- Part II:  Boron: Boron Chemistry -- New Candidates for Boron Carriers in BNCT -- Drugs for BNCT (BSH and BPA) -- Part III: Analysis and Imaging: Boron analysis and Boron Imaging -- Proteomic investigations for Boron Neutron Capture Therapy -- Analysis and Imaging: PET -- Localized quantitative detection and imaging of Boron by Magnetic Resonance -- Part IV: Physics: Boron Neutron Capture Therapy: Application of   Radiobiological Principles -- Tolerance of Healthy Tissues and Ideal Radiation Dose on BNCT -- Part VI: Clinical Applications: Clinical trials in BNCT – a challenging task -- External beam BNCT for Glioblastoma mulitforme -- Clinical results of sodium borocaptate (BSH)-based intra-operative boron neutron capture therapy (IO-BNCT) -- Boron neutron capture therapy for malignant meningiomas -- Feasibility for intramedullary spinal glioma -- BNCT for Advanced or Recurrent Head and Neck Cancer -- Studies on the possible application of BNCT to thyroid cancer -- Malignant Melanoma -- Application of Neutron Capture Therapy for Local Recurrenced Breast Cancer -- Recurrent breast cancers & inflammatory breast cancers.-  Liver Metastases -- Boron Neutron Capture Therapy for Children with Malignant Brain Tumors -- Part VII: Non malignant diseases: Prevention of vascular restenosis after vascular angioplasty.-Boron Neutron Capture Synovectomy -- Managerial Aspects of BNCT at a nuclear research reactor.
520 _aNeutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter. This in principle allows for tumor cell-selective high-LET particle radiotherapy. NCT is exciting scientifically but challenging clinically, and a key factor in success is close collaboration among very different disciplines. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.
650 0 _aMedicine.
650 0 _aRadiology, Medical.
650 0 _aRadiotherapy.
650 0 _aOncology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aRadiotherapy.
650 2 4 _aOncology.
650 2 4 _aImaging / Radiology.
700 1 _aWittig, Andrea.
_eeditor.
700 1 _aMoss, Raymond.
_eeditor.
700 1 _aNakagawa, Yoshinobu.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642313332
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-31334-9
912 _aZDB-2-SME
999 _c103337
_d103337