000 04197nam a22004695i 4500
001 978-3-642-22272-6
003 DE-He213
005 20140220083259.0
007 cr nn 008mamaa
008 111219s2012 gw | s |||| 0|eng d
020 _a9783642222726
_9978-3-642-22272-6
024 7 _a10.1007/978-3-642-22272-6
_2doi
050 4 _aQP34-38
072 7 _aMFG
_2bicssc
072 7 _aMED075000
_2bisacsh
082 0 4 _a612
_223
100 1 _aChouker, Alexander.
_eeditor.
245 1 0 _aStress Challenges and Immunity in Space
_h[electronic resource] :
_bFrom Mechanisms to Monitoring and Preventive Strategies /
_cedited by Alexander Chouker.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2012.
300 _aXIII, 469p. 74 illus., 50 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPart I: Prelude: A personal view from above.-A view from the ESA Topical Team Stress and Immunity. Part II: "Stress and Immunity"-research: a tight link between space and earth: What is Stress? The impact of everyday stressors on the immune system and health. Part III: Stress & Immune Allostasis in Space, from brain to immune responses: Neurobiological mechanisms of stress and glucocorticoid effects on learning and memory: implications for stress disorders on earth and in space -- The autonomous nervous system -- Circadian rhythm and stress -- Endocannabinoids, “new-old” mediators of stress homeostasis -- Immune System, definitions and stress-sensitive functions -- Innate Immunity under conditions of space flight.-NK Cells assessments: a thirty year old History of Immune stress interaction in Space -- Adaptive Immunity and Spaceflight.-Stress, Hypoxia, and Immune Response -- Gravitational force – triggered stress in cells of the immune system.-Microbial Stress: Spaceflight-induced alterations in microbial virulence and infectious disease risks for the crew -- Stress, Spaceflight, and Latent Herpes Viruses Reactivation -- Stress and Radiation-responsiveness. Part IV: Preventive and Diagnostic Tool & Strategies: Consideration on minimal or non-invasive monitoring applications -- Psychological Monitoring -- Breath gas analyses -- Microbiological environment, complementary procedures -- Thermoregulation -- Flow Cytometry.-  Radiation Sensitivity. Part V: Therapeutic Strategies: Intro.- Psychological -- Physical -- Nutrition -- Pharmacological.
520 _aStress of either a psychological or a physical nature can activate and/or paralyse humans’ innate or adaptive immunity. However, adequate immunity is crucial to the maintenance of health on earth and in space. During space flight, human physiology and health are challenged by complex environmental stressors (confinement, gravitation, oxygen tension, radiation) which might be at their most pronounced during lunar or interplanetary missions. This book adopts an interdisciplinary approach in seeking to identify the impact of living conditions in space on the adaptation of the immune system. While other publications have addressed the physiological changes that occur during space flight, to the authors’ knowledge this is the first book specifically to analyze the complex interaction of living conditions in space, the immune system, and astronauts’ health. It is explained how such analysis of the consequences of stress for the immune system may help in preventing, diagnosing, and counteracting immune-related alterations in health on earth as well as in space.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aImmunology.
650 0 _aNeurosciences.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Physiology.
650 2 4 _aMedicine/Public Health, general.
650 2 4 _aImmunology.
650 2 4 _aNeurosciences.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642222719
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-22272-6
912 _aZDB-2-SBL
999 _c102041
_d102041