000 03105nam a22004575i 4500
001 978-3-0348-0496-7
003 DE-He213
005 20140220083254.0
007 cr nn 008mamaa
008 130131s2012 sz | s |||| 0|eng d
020 _a9783034804967
_9978-3-0348-0496-7
024 7 _a10.1007/978-3-0348-0496-7
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aRainsford, K. D.
_eauthor.
245 1 0 _aIbuprofen: Pharmacology, Therapeutics and Side Effects
_h[electronic resource] /
_cby K. D. Rainsford.
264 1 _aBasel :
_bSpringer Basel :
_bImprint: Springer,
_c2012.
300 _aXX, 243 p. 62 illus., 23 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroduction -- Biodisposition in relation to actions -- Mechanisms of inflammation and sites of action of NSAIDs -- Clinical efficacy -- Drug derivatives and formulations -- General safety profile -- Gastro-intestinal toxicity -- Cardiovascular safety -- Renal toxicity -- Hepatic toxicity -- Other adverse reactions -- Global assessment of adverse reactions & human toxicology -- Overall assessment.
520 _aIbuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aToxicology.
650 0 _aRheumatology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aImmunology.
650 2 4 _aRheumatology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783034804950
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-0348-0496-7
912 _aZDB-2-SBL
999 _c101753
_d101753