000 04081nam a22005055i 4500
001 978-1-4614-3573-0
003 DE-He213
005 20140220083248.0
007 cr nn 008mamaa
008 120622s2012 xxu| s |||| 0|eng d
020 _a9781461435730
_9978-1-4614-3573-0
024 7 _a10.1007/978-1-4614-3573-0
_2doi
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
082 0 4 _a611.01816
_223
082 0 4 _a599.935
_223
100 1 _aKadenbach, Bernhard.
_eeditor.
245 1 0 _aMitochondrial Oxidative Phosphorylation
_h[electronic resource] :
_bNuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology /
_cedited by Bernhard Kadenbach.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2012.
300 _aXI, 372 p. 33 illus., 26 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v748
505 0 _aPreface -- Introduction -- Mitochondrial Dynamics: The Intersection of Form and Function -- Biogenesis of Mitochondrial Proteins -- Assembly Factors of Human Mitochondrial Respiratory Chain Complexes: Physiology and Pathophysiology -- Supramolecular Organization of the Mitochondrial Respiratory Chain: A New Challenge for the Mechanism and Control of Oxidative Phosphorylation -- Molecular Mechanisms of Superoxide Production by the Mitochondrial Respiratory Chain -- Studies on the Function and Regulation of Mitochondrial Uncoupling Proteins -- Evolution of the Couple Cytochrome C and Cytochrome C Oxidase in Primates -- Reaction Mechanism of Mammalian Mitochondrial Cytochrome C Oxidase -- Phosphorylation of Mammalian Cytochrome C and Cytochrome C Oxidase in the Regulation of Cell Destiny: Respiration, Apoptosis, and Human Disease -- Individual Biochemical Behavior Versus Biological Robustness: Spotlight on the Regulation of Cytochrome C Oxidase -- Bigenomic Regulation of Cytochrome C Oxidase in Neurons and the Tight Coupling Between Neuronal Activity and Energy Metabolism -- Cytochrome C Oxidase and its Role in Neurodegeneration and Neuroprotection -- The Many Clinical Faces of Cytochrome C Oxidase Deficiency -- Index.
520 _aThis book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aGene expression.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Genetics.
650 2 4 _aGene Expression.
650 2 4 _aCell Biology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461435723
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v748
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-3573-0
912 _aZDB-2-SBL
999 _c101398
_d101398