000 03562nam a22004695i 4500
001 978-1-4614-2403-1
003 DE-He213
005 20140220083246.0
007 cr nn 008mamaa
008 120224s2012 xxu| s |||| 0|eng d
020 _a9781461424031
_9978-1-4614-2403-1
024 7 _a10.1007/978-1-4614-2403-1
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aMittelman, Steven D.
_eeditor.
245 1 0 _aEnergy Balance and Hematologic Malignancies
_h[electronic resource] /
_cedited by Steven D. Mittelman, Nathan A. Berger.
264 1 _aBoston, MA :
_bSpringer US,
_c2012.
300 _aX, 184 p. 19 illus., 18 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aEnergy Balance and Cancer ;
_v5
505 0 _aPreface -- The Epidemiology of Obesity and Hematologic Malignancies -- Adipocytes, Lipid Metabolism and Hematopoiesis -- Mechanisms Linking Obesity and Leukemia Prognosis -- Obesity and Multiple Myeloma -- The Impact of Obesity on Pharmacokinetics and Dosing of Leukemia Chemotherapy -- The Impact of Obesity on Stem Cell Transplant -- Obesity Following Childhood Leukemia: Mechanisms and Consequences -- Physical Activity and Recovery from Hematological Malignancy -- Index.
520 _aThe obesity pandemic continues to increase on a world-wide basis with over 70% of the United States population being either overweight or obese. Hematologic malignancies have recently been identified among the obesity associated malignancies spanning the lifespan from childhood to the elderly and include leukemia, myeloma, lymphoma and others. In addition to the potential etiologic association between obesity and hematologic malignancies, the presence of obesity has profound effects on therapy by impacting pharmacokinetics of chemotherapeutic agents, dose, adipocyte metabolism and drug distribution. These may be particularly important in hematopoietic stem cell transplantation. Another important aspect of the association of obesity with hematologic malignancies is the increased incidence of obesity in children who successfully complete therapy for acute lymphoblastic leukemia. This and other observations indicate important relations between the hematopoietic systems and adipose tissue metabolism. Energy Balance in Hematologic Malignancies will provide an important volume in the series on Energy Balance and Cancer and serve as a basis for better understanding etiology, mechanisms, therapeutic implications and experimental approaches. While this book should be of specific interest and utility to all pediatric and adult hematologists and oncologists dealing with hematologic malignancies, it should also provide an important resource for all investigators concerned, from a clinical or research basis, with the impact of obesity and exercise on hematologic malignancies.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aCancer Research.
700 1 _aBerger, Nathan A.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461424024
830 0 _aEnergy Balance and Cancer ;
_v5
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-2403-1
912 _aZDB-2-SME
999 _c101277
_d101277