000 | 03562nam a22004695i 4500 | ||
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001 | 978-1-4614-2403-1 | ||
003 | DE-He213 | ||
005 | 20140220083246.0 | ||
007 | cr nn 008mamaa | ||
008 | 120224s2012 xxu| s |||| 0|eng d | ||
020 |
_a9781461424031 _9978-1-4614-2403-1 |
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024 | 7 |
_a10.1007/978-1-4614-2403-1 _2doi |
|
050 | 4 | _aRM1-950 | |
072 | 7 |
_aMMG _2bicssc |
|
072 | 7 |
_aMED071000 _2bisacsh |
|
082 | 0 | 4 |
_a615 _223 |
100 | 1 |
_aMittelman, Steven D. _eeditor. |
|
245 | 1 | 0 |
_aEnergy Balance and Hematologic Malignancies _h[electronic resource] / _cedited by Steven D. Mittelman, Nathan A. Berger. |
264 | 1 |
_aBoston, MA : _bSpringer US, _c2012. |
|
300 |
_aX, 184 p. 19 illus., 18 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
||
490 | 1 |
_aEnergy Balance and Cancer ; _v5 |
|
505 | 0 | _aPreface -- The Epidemiology of Obesity and Hematologic Malignancies -- Adipocytes, Lipid Metabolism and Hematopoiesis -- Mechanisms Linking Obesity and Leukemia Prognosis -- Obesity and Multiple Myeloma -- The Impact of Obesity on Pharmacokinetics and Dosing of Leukemia Chemotherapy -- The Impact of Obesity on Stem Cell Transplant -- Obesity Following Childhood Leukemia: Mechanisms and Consequences -- Physical Activity and Recovery from Hematological Malignancy -- Index. | |
520 | _aThe obesity pandemic continues to increase on a world-wide basis with over 70% of the United States population being either overweight or obese. Hematologic malignancies have recently been identified among the obesity associated malignancies spanning the lifespan from childhood to the elderly and include leukemia, myeloma, lymphoma and others. In addition to the potential etiologic association between obesity and hematologic malignancies, the presence of obesity has profound effects on therapy by impacting pharmacokinetics of chemotherapeutic agents, dose, adipocyte metabolism and drug distribution. These may be particularly important in hematopoietic stem cell transplantation. Another important aspect of the association of obesity with hematologic malignancies is the increased incidence of obesity in children who successfully complete therapy for acute lymphoblastic leukemia. This and other observations indicate important relations between the hematopoietic systems and adipose tissue metabolism. Energy Balance in Hematologic Malignancies will provide an important volume in the series on Energy Balance and Cancer and serve as a basis for better understanding etiology, mechanisms, therapeutic implications and experimental approaches. While this book should be of specific interest and utility to all pediatric and adult hematologists and oncologists dealing with hematologic malignancies, it should also provide an important resource for all investigators concerned, from a clinical or research basis, with the impact of obesity and exercise on hematologic malignancies. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aOncology. | |
650 | 0 | _aToxicology. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aPharmacology/Toxicology. |
650 | 2 | 4 | _aCancer Research. |
700 | 1 |
_aBerger, Nathan A. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9781461424024 |
830 | 0 |
_aEnergy Balance and Cancer ; _v5 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4614-2403-1 |
912 | _aZDB-2-SME | ||
999 |
_c101277 _d101277 |