000 03899nam a22005415i 4500
001 978-1-4614-1991-4
003 DE-He213
005 20140220083244.0
007 cr nn 008mamaa
008 111212s2012 xxu| s |||| 0|eng d
020 _a9781461419914
_9978-1-4614-1991-4
024 7 _a10.1007/978-1-4614-1991-4
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aPHVD
_2bicssc
072 7 _aSCI009000
_2bisacsh
082 0 4 _a571.4
_223
100 1 _aThiriet, Marc.
_eauthor.
245 1 0 _aSignaling at the Cell Surface in the Circulatory and Ventilatory Systems
_h[electronic resource] /
_cby Marc Thiriet.
264 1 _aNew York, NY :
_bSpringer New York,
_c2012.
300 _aXV, 982p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aBiomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems ;
_v3
505 0 _aIntroduction -- 1. Signal Transduction -- 2. Ion Carriers -- 3. Main Sets of Ion Channels and Pumps -- 4. Transmembrane Compound Carriers -- 5. Receptors of Cell-Matrix Mass Transfer -- 6. Receptors -- 7. G-Protein-Coupled Receptors -- 8. Receptor Protein Kinases -- 9. Receptor Tyrosine Phosphatases -- 10. Morphogen Receptors -- 11. Receptors of the Immune System -- Concluding Remarks.
520 _aThe volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 3 is devoted to the set of mediators of the cell surface, especially ion and molecular carriers and catalytic receptors that, once liganded and activated, initiate signal transduction pathways. Intracellular cascades of chemical reactions trigger the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Primary mediators are included in models of regulated cellular processes, but multiple secondary signaling components are discarded to allow simple, representative modeling and to manage their inverse problems. Reviews signaling pathways in the regulation of circulatory and respiratory function Describes ion and molecular carriers and receptors Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows
650 0 _aPhysics.
650 0 _aCardiology.
650 0 _aBiological models.
650 0 _aHydraulic engineering.
650 0 _aBiomedical engineering.
650 1 4 _aPhysics.
650 2 4 _aBiophysics and Biological Physics.
650 2 4 _aBiomedical Engineering.
650 2 4 _aMathematical and Computational Biology.
650 2 4 _aSystems Biology.
650 2 4 _aEngineering Fluid Dynamics.
650 2 4 _aCardiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461419907
830 0 _aBiomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems ;
_v3
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-1991-4
912 _aZDB-2-PHA
999 _c101175
_d101175