000 04347nam a22004575i 4500
001 978-1-4614-1960-0
003 DE-He213
005 20140220083244.0
007 cr nn 008mamaa
008 120214s2012 xxu| s |||| 0|eng d
020 _a9781461419600
_9978-1-4614-1960-0
024 7 _a10.1007/978-1-4614-1960-0
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aFruehauf, Stefan.
_eeditor.
245 1 0 _aNovel Developments in Stem Cell Mobilization
_h[electronic resource] :
_bFocus on CXCR4 /
_cedited by Stefan Fruehauf, W. Jens Zeller, Gary Calandra.
264 1 _aBoston, MA :
_bSpringer US,
_c2012.
300 _aXIV, 496p. 68 illus., 35 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- Preclinical Experience with AMD3100 for Mobilization of Hematopoietic Stem and Progenitor Cells -- Molecular Pharmacology of CXCR4 Inhibition -- Combination Strategies for Stem Cell Mobilization Targeting CXCR4 and S1P Receptors -- Should We Stay Or Should We Go Now? Cell Adhesion and Mobilization Pathways of Hematopoietic Cellls -- Role of the CXCR4/CXCL12 Axis in Hematopoietic Stem Cell Trafficking -- Early Studies of AMD3100/Plerixafor in Healthy Volunteers -- The Current Role of Plerixafor in Stem Cell Mobilization for Hematopoietic Stem Cell Transplantation -- Relevance and Clinical Implications of Tumor Cell Mobilization in Autologous Transplantation of Multiple Myeloma and non Hodgkin's lymphoma -- Plerixafor – Data from the Compassionate Use Program --  Stem Cell Mobilization with Chemomobilization plus Plerixafor in Hard-To-Mobilize Patients – The Experience at Kuopio University Hospital, Finland -- Blood Stem Cell Mobilization in Solid Tumors - Experience with Plerixafor and Alternative Ways of Hematopoietic Stem Cell Mobilization -- Mobilization with Chemotherapy+G-CSF+Plerixafor in Europe- the Italian experience -- Experience with Plerixafor in Poor Mobilizers -- CXCR4 Antagonists -- Application of CXCR4-Inhibitors in Leukemia -- CXCR4 Antagonists for the Treatment of CML -- Targeting CXCR4 in Chronic Lymphocytic Leukemia (CLL): Preclinical Rationale and Early Clinical Experience -- CXCR4-Blockade for Treatment of Breast Cancer -- Molecular Imaging of CXCR4 Receptor Expression in Tumors -- Potential Use of CXCR4 Antagonists to Mobilize Endothelial and Mesenchymal Stem Cells -- Strategies to Enhance Hematopoietic Stem Cell Engraftment Following Transplantation -- Mobilization for Gene Therapy -- Index.
520 _aRecently, the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development of effective antagonists. One antagonist, plerixafor, is now clinically approved for stem cell mobilization of lymphoma and myeloma patients. This progress allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoietic cells, i.e. leukemia cells. In preclinical studies, a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. CXCR4 antagonists are an exciting new class of compounds which are also used for the mobilization of angiogenic cells or for the treatment of solid tumors. This book provides concise reviews of novel developments, as well as possible future developments on CXCR4.  
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aPharmacology/Toxicology.
700 1 _aZeller, W. Jens.
_eeditor.
700 1 _aCalandra, Gary.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461419594
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-1960-0
912 _aZDB-2-SBL
999 _c101169
_d101169