000			03675nam a22004455i 4500
001			978-1-4614-1680-7
003			DE-He213
005			20140220083243.0
007			cr nn 008mamaa
008			120307s2012 xxu| s |||| 0|eng d
020			_a9781461416807 _9978-1-4614-1680-7
024	7		_a10.1007/978-1-4614-1680-7 _2doi
050		4	_aQR180-189.5
072		7	_aMJCM _2bicssc
072		7	_aMED044000 _2bisacsh
082	0	4	_a616.079 _223
100	1		_aLópez-Larrea, Carlos. _eeditor.
245	1	0	_aSelf and Nonself _h[electronic resource] / _cedited by Carlos López-Larrea.
264		1	_aNew York, NY : _bSpringer US, _c2012.
300			_aXXII, 318p. 35 illus., 22 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v738
505	0		_aThe Origin of the Bacterial Immune Response -- The Evolution of Self During the Transition to Multicellularity -- Glyconectin Glycans as the Self-Assembling Nano-Molecular-Velcrosystem Mediating Self-Nonself Recognition and Adhesion Implicated in Evolution of Multicellularity -- Neglected Biological Features in Cnidarians Self-Nonself Recognition -- Intracellular Inflammatory Sensors For Foreign Invaders and Substances of Self-Origin -- Nonself Perception in Plant Innate Immunity -- How Did Flowering Plants Learn to Avoid Blind Date Mistakes? Self‑Incompatibility in Plants and Comparisons with Nonself Rejection in the Immune Response -- Signaling Pathways that Regulate Life and Cell Death: Evolution of Apoptosis in the Context of Self‑Defense -- Sensing Necrotic Cells -- Sensing Endoplasmic Reticulum Stress -- Autophagy and Self-Defense -- Viruses and Host Evolution: Virus‑Mediated Self Identity -- The Evolution of Adaptive Immunity -- Epigenetic Code and Self-Identity -- Viral Immunomodulatory Proteins: Usurping Host Genes as a Survival Strategy -- The Emergence of the Major Histocompatilibility Complex -- MHC Signaling During Social Communication.
520			_aIn 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.
650		0	_aMedicine.
650		0	_aImmunology.
650	1	4	_aBiomedicine.
650	2	4	_aImmunology.
650	2	4	_aBiomedicine general.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461416791
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v738
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-1680-7
912			_aZDB-2-SBL
999			_c101115 _d101115