000 03176nam a22004455i 4500
001 978-1-4614-0659-4
003 DE-He213
005 20140220083239.0
007 cr nn 008mamaa
008 120307s2012 xxu| s |||| 0|eng d
020 _a9781461406594
_9978-1-4614-0659-4
024 7 _a10.1007/978-1-4614-0659-4
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aFuxreiter, Monika.
_eeditor.
245 1 0 _aFuzziness
_h[electronic resource] :
_bStructural Disorder in Protein Complexes /
_cedited by Monika Fuxreiter, Peter Tompa.
264 1 _aNew York, NY :
_bSpringer US,
_c2012.
300 _aXX, 190p. 50 illus., 4 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v725
505 0 _aFuzzy Complexes: A More Stochastic View of Protein Function -- Dynamic Fuzziness During Linker Histone Action -- Protein Flexibility in Regulation of Cell Proliferation: Advantages for Signaling and Opportunities for Novel Therapeutics -- Interplay Between Protein Order, Disorder and Oligomericity in Receptor Signaling -- Consequences of Fuzziness in the NFkB/IkBa Interaction -- Roles for Intrinsic Disorder and Fuzziness in Generating Context‑ Specific Function in Ultrabithorax, a Hox Transcription Factor -- Molecular Recognition by the EWS Transcriptional Activation Domain -- The Measles Virus Ntail‑Xd Complex: An Illustrative Example of Fuzziness -- Fuzziness in the Core of the Human Pathogenic Viruses HCV and HIV -- Structural Disorder and Protein Elasticity -- “Fuzziness” in the Cellular Interactome: A Historical Perspective.
520 _aDetailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.
650 0 _aMedicine.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aMolecular Medicine.
700 1 _aTompa, Peter.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461406587
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v725
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-0659-4
912 _aZDB-2-SBL
999 _c100901
_d100901