000 | 03176nam a22004455i 4500 | ||
---|---|---|---|
001 | 978-1-4614-0659-4 | ||
003 | DE-He213 | ||
005 | 20140220083239.0 | ||
007 | cr nn 008mamaa | ||
008 | 120307s2012 xxu| s |||| 0|eng d | ||
020 |
_a9781461406594 _9978-1-4614-0659-4 |
||
024 | 7 |
_a10.1007/978-1-4614-0659-4 _2doi |
|
050 | 4 | _aR-RZ | |
072 | 7 |
_aMBGR _2bicssc |
|
072 | 7 |
_aMED000000 _2bisacsh |
|
082 | 0 | 4 |
_a610 _223 |
100 | 1 |
_aFuxreiter, Monika. _eeditor. |
|
245 | 1 | 0 |
_aFuzziness _h[electronic resource] : _bStructural Disorder in Protein Complexes / _cedited by Monika Fuxreiter, Peter Tompa. |
264 | 1 |
_aNew York, NY : _bSpringer US, _c2012. |
|
300 |
_aXX, 190p. 50 illus., 4 illus. in color. _bonline resource. |
||
336 |
_atext _btxt _2rdacontent |
||
337 |
_acomputer _bc _2rdamedia |
||
338 |
_aonline resource _bcr _2rdacarrier |
||
347 |
_atext file _bPDF _2rda |
||
490 | 1 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v725 |
|
505 | 0 | _aFuzzy Complexes: A More Stochastic View of Protein Function -- Dynamic Fuzziness During Linker Histone Action -- Protein Flexibility in Regulation of Cell Proliferation: Advantages for Signaling and Opportunities for Novel Therapeutics -- Interplay Between Protein Order, Disorder and Oligomericity in Receptor Signaling -- Consequences of Fuzziness in the NFkB/IkBa Interaction -- Roles for Intrinsic Disorder and Fuzziness in Generating Context‑ Specific Function in Ultrabithorax, a Hox Transcription Factor -- Molecular Recognition by the EWS Transcriptional Activation Domain -- The Measles Virus Ntail‑Xd Complex: An Illustrative Example of Fuzziness -- Fuzziness in the Core of the Human Pathogenic Viruses HCV and HIV -- Structural Disorder and Protein Elasticity -- “Fuzziness” in the Cellular Interactome: A Historical Perspective. | |
520 | _aDetailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions. | ||
650 | 0 | _aMedicine. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aBiomedicine general. |
650 | 2 | 4 | _aMolecular Medicine. |
700 | 1 |
_aTompa, Peter. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9781461406587 |
830 | 0 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v725 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4614-0659-4 |
912 | _aZDB-2-SBL | ||
999 |
_c100901 _d100901 |