000			04140nam a22004935i 4500
001			978-1-4419-5774-0
003			DE-He213
005			20140220083232.0
007			cr nn 008mamaa
008			120204s2012 xxu| s |||| 0|eng d
020			_a9781441957740 _9978-1-4419-5774-0
024	7		_a10.1007/978-1-4419-5774-0 _2doi
050		4	_aRC927-927.5
072		7	_aMJM _2bicssc
072		7	_aMED083000 _2bisacsh
082	0	4	_a616.723 _223
100	1		_aVarga, John. _eeditor.
245	1	0	_aScleroderma _h[electronic resource] : _bFrom Pathogenesis to Comprehensive Management / _cedited by John Varga, Christopher P. Denton, Fredrick M. Wigley.
250			_a1.
264		1	_aBoston, MA : _bSpringer US, _c2012.
300			_aXX, 689 p. 163 illus., 131 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aForeword -- Preface -- Historical Perspective.-Therapeutic evolution: a professor’s view -- Overview: Epidemiology, Genetics and Classification.-Epidemiology and Environmental Risk Factors.- Genetic Factors -- Disease Subsets in Clinical Practice.-Evolving Concepts of Diagnosis and Classification -- Disease Classification using Molecular Signatures.-Localized Scleroderma -- Juvenile Systemic Scleroderma.-Scleroderma Mimics -- Localized Forms of Scleroderma in Adults.-Overview: Integrated Pathogenesis -- Immunological Mechanisms.-Innate Immunity -- Autoantibodies in Pathogenesis -- The Clinical Aspects of Autoantibodies -- Mechanisms of Vascular Disease.-Vascular Biomarkers -- Mechanisms of Fibrosis -- Fibrosis: Insights from the stiff skin syndrome -- Biomarkers of Fibrosis -- Overview of Animal Models.-Overview: Cardiovascular Manifestations and Management.-Raynaud Phenomenon.-Nailfold Capillaroscopy -- Systemic Vascular Disease -- Scleroderma Renal Crisis -- Cardiac Involvement.-Erectile Dysfunction.-Overview: Pulmonary manifestations and management.-Clinical Assessment of Lung Disease -- Computerized Tomography of Interstitial Lung Disease.-Treatment of interstitial lung disease.-Clinical Assessment of Pulmonary Hypertension.-Treatment of Pulmonary Hypertension -- Complex Challenges of Pulmonary Hypertension -- Overview: Gastrointestinal Manifestations and Management -- Upper Gastrointestinal Tract.-Small and Large Intestinal Involvement.-Evaluation and Management of Skin Disease.-Skeletal Muscle Involvement.-  Tendons, Joints and Bone -- Pregnancy.-Overlooked Manifestations -- Principles of Management.-Immunomodulatory Therapies.-Cell-Based Therapies -- Investigative Approaches to Drug Therapy.-Complementary and alternate medicine approaches.-Physical and occupational therapy -- Evaluation and Management of Psychosocial Issues.-Issues in Clinical Trial Design -- Measuring Disease Activity -- Patient Reported Outcomes. .
520			_aThis essential resource presents the most up-to-date information on scleroderma. A clear and concise synthesis of current concepts in pathogenesis and modern approaches to management, this book is comprised of the authoritative work of international experts. With an integrated multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. It is a valuable resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.
650		0	_aMedicine.
650		0	_aInternal medicine.
650		0	_aPneumology.
650		0	_aRheumatology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aRheumatology.
650	2	4	_aInternal Medicine.
650	2	4	_aPneumology/Respiratory System.
700	1		_aDenton, Christopher P. _eeditor.
700	1		_aWigley, Fredrick M. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441957733
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4419-5774-0
912			_aZDB-2-SME
999			_c100512 _d100512