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Advances in Biology and Therapy of Multiple Myeloma [electronic resource] : Volume 2: Translational and Clinical Research / edited by Nikhil C. Munshi, Kenneth C. Anderson.

By: Munshi, Nikhil C [editor.].
Contributor(s): Anderson, Kenneth C [editor.] | SpringerLink (Online service).
Material type: materialTypeLabelBookPublisher: New York, NY : Springer New York : Imprint: Springer, 2013Description: X, 287 p. 7 illus., 5 illus. in color. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9781461452607.Subject(s): Medicine | Oncology | Toxicology | Biomedicine | Cancer Research | Pharmacology/ToxicologyDDC classification: 614.5999 Online resources: Click here to access online
Contents:
T cell responses in myeloma -- Novel antigenic targets for immunotherapy in myeloma -- Antibody-based therapies in Multiple Myeloma -- Defining multiple myeloma as a target for DNA gene fusion vaccines -- Harnessing allogeneic immunity for anti-myeloma response -- Dendritic cell and peptide-based vaccination in myeloma -- New Proteasome inhibitors -- Newer Imids -- New agents in myeloma -- Early Combination Studies in MM -- The effect of novel antimyeloma agents on bone metabolism -- Index.
In: Springer eBooksSummary: Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients.   This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.
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T cell responses in myeloma -- Novel antigenic targets for immunotherapy in myeloma -- Antibody-based therapies in Multiple Myeloma -- Defining multiple myeloma as a target for DNA gene fusion vaccines -- Harnessing allogeneic immunity for anti-myeloma response -- Dendritic cell and peptide-based vaccination in myeloma -- New Proteasome inhibitors -- Newer Imids -- New agents in myeloma -- Early Combination Studies in MM -- The effect of novel antimyeloma agents on bone metabolism -- Index.

Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients.   This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact.

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