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Development of Innovative Drugs via Modeling with MATLAB [electronic resource] : A Practical Guide / by Ronald Gieschke, Daniel Serafin.

By: Gieschke, Ronald [author.].
Contributor(s): Serafin, Daniel [author.] | SpringerLink (Online service).
Material type: materialTypeLabelBookPublisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014Description: XV, 399 p. 192 illus., 112 illus. in color. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9783642397653.Subject(s): Medicine | Toxicology | Pharmaceutical technology | Computer simulation | Biology -- Data processing | Biomedicine | Pharmacology/Toxicology | Pharmaceutical Sciences/Technology | Simulation and Modeling | Computer Appl. in Life SciencesDDC classification: 615 Online resources: Click here to access online
Contents:
Background of pharmacologic modeling -- First example of a computational model -- Differential equations in MATLAB -- Pharmacologic modeling -- Drug-disease modeling -- Population analyses -- Clinical trial simulation -- Graphics-based modeling -- Outlook -- Appendix A: Hints to MATLAB programs -- Appendix B: Solution to exercises.
In: Springer eBooksSummary: The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens? Written from the industry perspective and based on many years of experience, this book offers: §  Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs §  Guidance for exploration and modification of these programs to enhance the understanding of key principles §  Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature §  A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling. Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.
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Background of pharmacologic modeling -- First example of a computational model -- Differential equations in MATLAB -- Pharmacologic modeling -- Drug-disease modeling -- Population analyses -- Clinical trial simulation -- Graphics-based modeling -- Outlook -- Appendix A: Hints to MATLAB programs -- Appendix B: Solution to exercises.

The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens? Written from the industry perspective and based on many years of experience, this book offers: §  Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs §  Guidance for exploration and modification of these programs to enhance the understanding of key principles §  Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature §  A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling. Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.

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