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Tumor Metabolome Targeting and Drug Development [electronic resource] / edited by Steven Kanner.

By: Kanner, Steven [editor.].
Contributor(s): SpringerLink (Online service).
Material type: materialTypeLabelBookSeries: Cancer Drug Discovery and Development: Publisher: New York, NY : Springer New York : Imprint: Springer, 2014Description: VIII, 198 p. 22 illus., 12 illus. in color. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9781461495451.Subject(s): Medicine | Oncology | Toxicology | Metabolism | Biomedicine | Cancer Research | Metabolomics | Molecular Medicine | Pharmacology/ToxicologyDDC classification: 614.5999 Online resources: Click here to access online
Contents:
Tumor cell metabolic reprogramming and drug targeting -- Cancer metabolism: a nexus of matter, energy and reactive oxygen species -- Regulating mitochondrial respiration in cancer -- Regulation of cancer cell metabolism by hypoxia -- Glucose metabolism and the anti-oxidative defence system in cancer cells: Options for application of ROS-based anticancer drugs -- Modulating autophagy and the “reverse Warburg effect” -- Metabolic adaptation in reprogrammed cancer cells -- Index.
In: Springer eBooksSummary: In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.  The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate.  However, the metabolism of malignant cells generally varies from that of normal cells.  These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options  Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.  
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Tumor cell metabolic reprogramming and drug targeting -- Cancer metabolism: a nexus of matter, energy and reactive oxygen species -- Regulating mitochondrial respiration in cancer -- Regulation of cancer cell metabolism by hypoxia -- Glucose metabolism and the anti-oxidative defence system in cancer cells: Options for application of ROS-based anticancer drugs -- Modulating autophagy and the “reverse Warburg effect” -- Metabolic adaptation in reprogrammed cancer cells -- Index.

In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.  The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate.  However, the metabolism of malignant cells generally varies from that of normal cells.  These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options  Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.  

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